Found 6 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Endothelin-converting enzyme 1
(Homo sapiens (Human)) | BDBM50287151
((R)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2...)Show SMILES CC(O)[C@@H](NC(=O)C(Cc1ccccc1)CP(O)(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(O)=O Show InChI InChI=1S/C30H35N2O8P/c1-21(33)27(29(35)36)32-28(34)25(17-22-11-5-2-6-12-22)20-41(38,39)26(18-23-13-7-3-8-14-23)31-30(37)40-19-24-15-9-4-10-16-24/h2-16,21,25-27,33H,17-20H2,1H3,(H,31,37)(H,32,34)(H,35,36)(H,38,39)/t21?,25?,26-,27-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of endothelin-converting enzyme in human umbilical vein endothelial cells |
Bioorg Med Chem Lett 6: 1323-1326 (1996)
Article DOI: 10.1016/0960-894X(96)00227-2 BindingDB Entry DOI: 10.7270/Q2Q81DKV |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50287151
((R)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2...)Show SMILES CC(O)[C@@H](NC(=O)C(Cc1ccccc1)CP(O)(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(O)=O Show InChI InChI=1S/C30H35N2O8P/c1-21(33)27(29(35)36)32-28(34)25(17-22-11-5-2-6-12-22)20-41(38,39)26(18-23-13-7-3-8-14-23)31-30(37)40-19-24-15-9-4-10-16-24/h2-16,21,25-27,33H,17-20H2,1H3,(H,31,37)(H,32,34)(H,35,36)(H,38,39)/t21?,25?,26-,27-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of neutral endopeptidase in human umbilical vein endothelial cells |
Bioorg Med Chem Lett 6: 1323-1326 (1996)
Article DOI: 10.1016/0960-894X(96)00227-2 BindingDB Entry DOI: 10.7270/Q2Q81DKV |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50366431
(CHEMBL1794047)Show SMILES C[C@H](O)[C@@H](NC(=O)C(Cc1ccccc1)CP(O)(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(O)=O Show InChI InChI=1S/C30H35N2O8P/c1-21(33)27(29(35)36)32-28(34)25(17-22-11-5-2-6-12-22)20-41(38,39)26(18-23-13-7-3-8-14-23)31-30(37)40-19-24-15-9-4-10-16-24/h2-16,21,25-27,33H,17-20H2,1H3,(H,31,37)(H,32,34)(H,35,36)(H,38,39)/t21-,25?,26+,27+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of neutral endopeptidase in human umbilical vein endothelial cells |
Bioorg Med Chem Lett 6: 1323-1326 (1996)
Article DOI: 10.1016/0960-894X(96)00227-2 BindingDB Entry DOI: 10.7270/Q2Q81DKV |
More data for this Ligand-Target Pair | |
Endothelin-converting enzyme 1
(Homo sapiens (Human)) | BDBM50366431
(CHEMBL1794047)Show SMILES C[C@H](O)[C@@H](NC(=O)C(Cc1ccccc1)CP(O)(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(O)=O Show InChI InChI=1S/C30H35N2O8P/c1-21(33)27(29(35)36)32-28(34)25(17-22-11-5-2-6-12-22)20-41(38,39)26(18-23-13-7-3-8-14-23)31-30(37)40-19-24-15-9-4-10-16-24/h2-16,21,25-27,33H,17-20H2,1H3,(H,31,37)(H,32,34)(H,35,36)(H,38,39)/t21-,25?,26+,27+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of endothelin-converting enzyme in human umbilical vein endothelial cells |
Bioorg Med Chem Lett 6: 1323-1326 (1996)
Article DOI: 10.1016/0960-894X(96)00227-2 BindingDB Entry DOI: 10.7270/Q2Q81DKV |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50366431
(CHEMBL1794047)Show SMILES C[C@H](O)[C@@H](NC(=O)C(Cc1ccccc1)CP(O)(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(O)=O Show InChI InChI=1S/C30H35N2O8P/c1-21(33)27(29(35)36)32-28(34)25(17-22-11-5-2-6-12-22)20-41(38,39)26(18-23-13-7-3-8-14-23)31-30(37)40-19-24-15-9-4-10-16-24/h2-16,21,25-27,33H,17-20H2,1H3,(H,31,37)(H,32,34)(H,35,36)(H,38,39)/t21-,25?,26+,27+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of neutral endopeptidase in human umbilical vein endothelial cells |
Bioorg Med Chem Lett 6: 1323-1326 (1996)
Article DOI: 10.1016/0960-894X(96)00227-2 BindingDB Entry DOI: 10.7270/Q2Q81DKV |
More data for this Ligand-Target Pair | |
Endothelin-converting enzyme 1
(Homo sapiens (Human)) | BDBM50366431
(CHEMBL1794047)Show SMILES C[C@H](O)[C@@H](NC(=O)C(Cc1ccccc1)CP(O)(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(O)=O Show InChI InChI=1S/C30H35N2O8P/c1-21(33)27(29(35)36)32-28(34)25(17-22-11-5-2-6-12-22)20-41(38,39)26(18-23-13-7-3-8-14-23)31-30(37)40-19-24-15-9-4-10-16-24/h2-16,21,25-27,33H,17-20H2,1H3,(H,31,37)(H,32,34)(H,35,36)(H,38,39)/t21-,25?,26+,27+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of endothelin-converting enzyme in human umbilical vein endothelial cells |
Bioorg Med Chem Lett 6: 1323-1326 (1996)
Article DOI: 10.1016/0960-894X(96)00227-2 BindingDB Entry DOI: 10.7270/Q2Q81DKV |
More data for this Ligand-Target Pair | |