Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Chymase
(Homo sapiens (Human)) | BDBM100747
(CHEMBL2397007 | US8507714, 151)Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1cncc(c1)C(O)=O |r| Show InChI InChI=1S/C23H25ClN4O6/c1-3-18(14-7-16(22(31)32)10-25-9-14)27-23(33)28-12-20(29)26-11-15(21(28)30)6-13-8-17(24)4-5-19(13)34-2/h4-5,7-10,15,18H,3,6,11-12H2,1-2H3,(H,26,29)(H,27,33)(H,31,32)/t15-,18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Company, Limited
US Patent
| Assay Description Inhibitory activity of the compounds for recombinant human chymase was measured by method of Pasztor et al. (Pasztor et al., Acta Biol. Hung. 42:285-... |
US Patent US8507714 (2013)
BindingDB Entry DOI: 10.7270/Q2H130N8 |
More data for this Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100747
(CHEMBL2397007 | US8507714, 151)Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1cncc(c1)C(O)=O |r| Show InChI InChI=1S/C23H25ClN4O6/c1-3-18(14-7-16(22(31)32)10-25-9-14)27-23(33)28-12-20(29)26-11-15(21(28)30)6-13-8-17(24)4-5-19(13)34-2/h4-5,7-10,15,18H,3,6,11-12H2,1-2H3,(H,26,29)(H,27,33)(H,31,32)/t15-,18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub... |
Bioorg Med Chem 21: 4233-49 (2013)
Article DOI: 10.1016/j.bmc.2013.04.079 BindingDB Entry DOI: 10.7270/Q2CF9RHR |
More data for this Ligand-Target Pair | |