Found 16 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from human Y2R expressed in CHO cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.251 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from human Y2R expressed in CHO cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from human Y5R expressed in HEK293 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PP from human Y4R expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from human Y5R expressed in HEK293 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PP from human Y4R expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y2R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y5R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 790 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y5R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y2R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 500 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y4R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50466553
(CHEMBL4279794)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C185H277N53O55/c1-15-93(10)146(190)175(286)219-119(29-18-19-63-186)179(290)237-69-25-35-135(237)173(284)216-116(55-60-142(252)253)151(262)209-96(13)178(289)236-68-24-34-134(236)172(283)205-85-140(249)210-114(54-59-141(250)251)156(267)230-130(82-145(258)259)161(272)208-95(12)150(261)233-133(87-240)180(291)238-70-26-36-136(238)174(285)217-118(57-62-144(256)257)158(269)215-117(56-61-143(254)255)159(270)220-121(72-90(4)5)163(274)228-128(80-138(188)247)168(279)213-110(30-20-64-200-182(191)192)153(264)223-124(75-99-39-47-105(243)48-40-99)166(277)224-123(74-98-37-45-104(242)46-38-98)160(271)207-94(11)149(260)232-132(86-239)171(282)222-120(71-89(2)3)162(273)212-111(31-21-65-201-183(193)194)154(265)227-127(79-103-84-199-88-206-103)167(278)225-125(76-100-41-49-106(244)50-42-100)165(276)221-122(73-91(6)7)164(275)229-129(81-139(189)248)169(280)226-126(78-102-83-204-109-28-17-16-27-108(102)109)170(281)234-147(92(8)9)176(287)235-148(97(14)241)177(288)218-113(33-23-67-203-185(197)198)152(263)214-115(53-58-137(187)246)157(268)211-112(32-22-66-202-184(195)196)155(266)231-131(181(292)293)77-101-43-51-107(245)52-44-101/h16-17,27-28,37-52,83-84,88-97,110-136,146-148,204,239-245H,15,18-26,29-36,53-82,85-87,186,190H2,1-14H3,(H2,187,246)(H2,188,247)(H2,189,248)(H,199,206)(H,205,283)(H,207,271)(H,208,272)(H,209,262)(H,210,249)(H,211,268)(H,212,273)(H,213,279)(H,214,263)(H,215,269)(H,216,284)(H,217,285)(H,218,288)(H,219,286)(H,220,270)(H,221,276)(H,222,282)(H,223,264)(H,224,277)(H,225,278)(H,226,280)(H,227,265)(H,228,274)(H,229,275)(H,230,267)(H,231,266)(H,232,260)(H,233,261)(H,234,281)(H,235,287)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,292,293)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t93-,94-,95-,96-,97+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 501 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y4R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |