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Target
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Ki
IC50
Kd
EC50
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Compile Data Set for Download or QSAR
Marvin 2D Structure
The following exact ligands are found in BindingDB
Wt: 1811.0
BDBM50550631
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Gamma-aminobutyric acid type B receptor subunit 1/2
(Homo sapiens (Human))
BDBM50550631
(CHEMBL4756657)
Show SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)CN)C(=O)N[C@@H](CS)C(N)=O |r|
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
2.40
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.8b01343
BindingDB Entry DOI:
10.7270/Q2PR80MH
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha9/alpha10
(RAT-Rattus norvegicus)
BDBM50550631
(CHEMBL4756657)
Show SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)CN)C(=O)N[C@@H](CS)C(N)=O |r|
Show InChI
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
28
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -80 mV holding potential ...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.8b01343
BindingDB Entry DOI:
10.7270/Q2PR80MH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha9/alpha10
(Homo sapiens (Human))
BDBM50550631
(CHEMBL4756657)
Show SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)CN)C(=O)N[C@@H](CS)C(N)=O |r|
Show InChI
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
1.00E+3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -80 mV holding potentia...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.8b01343
BindingDB Entry DOI:
10.7270/Q2PR80MH
More data for this
Ligand-Target Pair