Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50441968
(CHEMBL2440189)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)C1(C)C |r,wU:93.94,89.91,87.88,30.39,8.17,2.2,45.46,61.62,76.77,wD:104.105,20.28,4.4,53.54,62.64,69.70,70.73,(16.35,-26.48,;16.35,-24.94,;17.69,-24.17,;19.02,-24.94,;17.69,-22.63,;16.35,-21.86,;15.02,-22.63,;15.02,-24.17,;13.68,-21.86,;13.68,-20.32,;15.02,-19.55,;16.34,-20.31,;17.69,-19.54,;17.68,-18,;19.01,-17.22,;16.33,-17.23,;15.02,-18.01,;12.35,-22.63,;11.02,-21.86,;11.02,-20.32,;9.69,-22.63,;9.69,-24.17,;11.02,-24.94,;12.44,-24.32,;13.47,-25.46,;12.7,-26.8,;11.18,-26.48,;8.35,-21.86,;7.02,-22.63,;7.02,-24.17,;5.68,-21.86,;5.68,-20.32,;7.02,-19.55,;7.02,-18.01,;8.35,-17.24,;8.35,-15.7,;7.02,-14.93,;9.69,-14.93,;4.35,-22.63,;3.01,-21.86,;1.67,-22.63,;3.01,-20.32,;19.02,-21.86,;19.02,-20.32,;20.36,-22.63,;21.7,-21.86,;21.7,-20.32,;23.03,-19.55,;24.36,-20.32,;23.03,-18.01,;23.03,-22.63,;23.03,-24.17,;24.36,-21.86,;25.69,-22.63,;25.69,-24.17,;27.03,-24.94,;27.03,-26.48,;28.36,-24.17,;27.03,-21.86,;27.03,-20.32,;28.36,-22.63,;29.7,-21.86,;29.7,-20.32,;31.03,-19.55,;28.36,-19.55,;28.36,-18.01,;31.03,-22.63,;31.03,-24.17,;32.37,-21.86,;33.7,-22.63,;33.7,-24.17,;32.37,-24.94,;35.04,-24.94,;35.04,-21.87,;35.04,-20.32,;36.38,-22.63,;37.7,-21.87,;37.7,-20.32,;39.04,-19.55,;39.04,-18.01,;40.37,-17.24,;40.37,-15.7,;39.04,-14.93,;41.71,-14.93,;39.05,-22.64,;39.05,-24.17,;40.36,-21.88,;41.7,-22.65,;43.18,-22.32,;43.51,-23.86,;44.85,-24.63,;44.85,-26.17,;46.18,-23.86,;47.52,-24.63,;48.85,-23.86,;50.18,-24.63,;51.51,-23.86,;52.85,-24.63,;54.18,-23.86,;54.18,-22.32,;55.52,-24.63,;47.52,-26.17,;46.18,-26.95,;48.85,-26.95,;48.85,-28.49,;47.52,-29.25,;47.52,-30.79,;48.85,-31.57,;48.85,-33.11,;47.52,-33.88,;47.52,-35.42,;46.18,-33.11,;46.18,-31.57,;50.18,-29.25,;50.19,-30.79,;51.52,-28.48,;42.04,-24.17,;40.53,-24.53,;42.39,-25.67,)| Show InChI InChI=1S/C77H123N25O17/c1-11-39(5)59(100-70(116)54(32-44-21-25-47(106)26-22-44)96-67(113)55(33-45-36-86-37-90-45)97-64(110)49(91-42(8)104)16-13-27-87-74(80)81)71(117)98-56(35-58(78)107)68(114)95-53(30-38(3)4)69(115)101-60(40(6)12-2)72(118)102-61(41(7)103)73(119)93-51(18-15-29-89-76(84)85)66(112)99-57-34-48(77(57,9)10)63(109)92-50(17-14-28-88-75(82)83)65(111)94-52(62(79)108)31-43-19-23-46(105)24-20-43/h19-26,36-41,48-57,59-61,103,105-106H,11-18,27-35H2,1-10H3,(H2,78,107)(H2,79,108)(H,86,90)(H,91,104)(H,92,109)(H,93,119)(H,94,111)(H,95,114)(H,96,113)(H,97,110)(H,98,117)(H,99,112)(H,100,116)(H,101,115)(H,102,118)(H4,80,81,87)(H4,82,83,88)(H4,84,85,89)/t39-,40-,41+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,59-,60-,61-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Displacement of Cy5-pNPY from human Y2 receptor expressed in CHO cells after 90 to 120 mins by flow cytometry |
J Med Chem 56: 8422-31 (2013)
Article DOI: 10.1021/jm4008505
BindingDB Entry DOI: 10.7270/Q25X2BC9 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50441968
(CHEMBL2440189)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)C1(C)C |r,wU:93.94,89.91,87.88,30.39,8.17,2.2,45.46,61.62,76.77,wD:104.105,20.28,4.4,53.54,62.64,69.70,70.73,(16.35,-26.48,;16.35,-24.94,;17.69,-24.17,;19.02,-24.94,;17.69,-22.63,;16.35,-21.86,;15.02,-22.63,;15.02,-24.17,;13.68,-21.86,;13.68,-20.32,;15.02,-19.55,;16.34,-20.31,;17.69,-19.54,;17.68,-18,;19.01,-17.22,;16.33,-17.23,;15.02,-18.01,;12.35,-22.63,;11.02,-21.86,;11.02,-20.32,;9.69,-22.63,;9.69,-24.17,;11.02,-24.94,;12.44,-24.32,;13.47,-25.46,;12.7,-26.8,;11.18,-26.48,;8.35,-21.86,;7.02,-22.63,;7.02,-24.17,;5.68,-21.86,;5.68,-20.32,;7.02,-19.55,;7.02,-18.01,;8.35,-17.24,;8.35,-15.7,;7.02,-14.93,;9.69,-14.93,;4.35,-22.63,;3.01,-21.86,;1.67,-22.63,;3.01,-20.32,;19.02,-21.86,;19.02,-20.32,;20.36,-22.63,;21.7,-21.86,;21.7,-20.32,;23.03,-19.55,;24.36,-20.32,;23.03,-18.01,;23.03,-22.63,;23.03,-24.17,;24.36,-21.86,;25.69,-22.63,;25.69,-24.17,;27.03,-24.94,;27.03,-26.48,;28.36,-24.17,;27.03,-21.86,;27.03,-20.32,;28.36,-22.63,;29.7,-21.86,;29.7,-20.32,;31.03,-19.55,;28.36,-19.55,;28.36,-18.01,;31.03,-22.63,;31.03,-24.17,;32.37,-21.86,;33.7,-22.63,;33.7,-24.17,;32.37,-24.94,;35.04,-24.94,;35.04,-21.87,;35.04,-20.32,;36.38,-22.63,;37.7,-21.87,;37.7,-20.32,;39.04,-19.55,;39.04,-18.01,;40.37,-17.24,;40.37,-15.7,;39.04,-14.93,;41.71,-14.93,;39.05,-22.64,;39.05,-24.17,;40.36,-21.88,;41.7,-22.65,;43.18,-22.32,;43.51,-23.86,;44.85,-24.63,;44.85,-26.17,;46.18,-23.86,;47.52,-24.63,;48.85,-23.86,;50.18,-24.63,;51.51,-23.86,;52.85,-24.63,;54.18,-23.86,;54.18,-22.32,;55.52,-24.63,;47.52,-26.17,;46.18,-26.95,;48.85,-26.95,;48.85,-28.49,;47.52,-29.25,;47.52,-30.79,;48.85,-31.57,;48.85,-33.11,;47.52,-33.88,;47.52,-35.42,;46.18,-33.11,;46.18,-31.57,;50.18,-29.25,;50.19,-30.79,;51.52,-28.48,;42.04,-24.17,;40.53,-24.53,;42.39,-25.67,)| Show InChI InChI=1S/C77H123N25O17/c1-11-39(5)59(100-70(116)54(32-44-21-25-47(106)26-22-44)96-67(113)55(33-45-36-86-37-90-45)97-64(110)49(91-42(8)104)16-13-27-87-74(80)81)71(117)98-56(35-58(78)107)68(114)95-53(30-38(3)4)69(115)101-60(40(6)12-2)72(118)102-61(41(7)103)73(119)93-51(18-15-29-89-76(84)85)66(112)99-57-34-48(77(57,9)10)63(109)92-50(17-14-28-88-75(82)83)65(111)94-52(62(79)108)31-43-19-23-46(105)24-20-43/h19-26,36-41,48-57,59-61,103,105-106H,11-18,27-35H2,1-10H3,(H2,78,107)(H2,79,108)(H,86,90)(H,91,104)(H,92,109)(H,93,119)(H,94,111)(H,95,114)(H,96,113)(H,97,110)(H,98,117)(H,99,112)(H,100,116)(H,101,115)(H,102,118)(H4,80,81,87)(H4,82,83,88)(H4,84,85,89)/t39-,40-,41+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,59-,60-,61-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Displacement of Cy5-[K4]hPP from human Y4 receptor expressed in CHO cells after 90 to 120 mins by flow cytometry |
J Med Chem 56: 8422-31 (2013)
Article DOI: 10.1021/jm4008505
BindingDB Entry DOI: 10.7270/Q25X2BC9 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50441968
(CHEMBL2440189)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)C1(C)C |r,wU:93.94,89.91,87.88,30.39,8.17,2.2,45.46,61.62,76.77,wD:104.105,20.28,4.4,53.54,62.64,69.70,70.73,(16.35,-26.48,;16.35,-24.94,;17.69,-24.17,;19.02,-24.94,;17.69,-22.63,;16.35,-21.86,;15.02,-22.63,;15.02,-24.17,;13.68,-21.86,;13.68,-20.32,;15.02,-19.55,;16.34,-20.31,;17.69,-19.54,;17.68,-18,;19.01,-17.22,;16.33,-17.23,;15.02,-18.01,;12.35,-22.63,;11.02,-21.86,;11.02,-20.32,;9.69,-22.63,;9.69,-24.17,;11.02,-24.94,;12.44,-24.32,;13.47,-25.46,;12.7,-26.8,;11.18,-26.48,;8.35,-21.86,;7.02,-22.63,;7.02,-24.17,;5.68,-21.86,;5.68,-20.32,;7.02,-19.55,;7.02,-18.01,;8.35,-17.24,;8.35,-15.7,;7.02,-14.93,;9.69,-14.93,;4.35,-22.63,;3.01,-21.86,;1.67,-22.63,;3.01,-20.32,;19.02,-21.86,;19.02,-20.32,;20.36,-22.63,;21.7,-21.86,;21.7,-20.32,;23.03,-19.55,;24.36,-20.32,;23.03,-18.01,;23.03,-22.63,;23.03,-24.17,;24.36,-21.86,;25.69,-22.63,;25.69,-24.17,;27.03,-24.94,;27.03,-26.48,;28.36,-24.17,;27.03,-21.86,;27.03,-20.32,;28.36,-22.63,;29.7,-21.86,;29.7,-20.32,;31.03,-19.55,;28.36,-19.55,;28.36,-18.01,;31.03,-22.63,;31.03,-24.17,;32.37,-21.86,;33.7,-22.63,;33.7,-24.17,;32.37,-24.94,;35.04,-24.94,;35.04,-21.87,;35.04,-20.32,;36.38,-22.63,;37.7,-21.87,;37.7,-20.32,;39.04,-19.55,;39.04,-18.01,;40.37,-17.24,;40.37,-15.7,;39.04,-14.93,;41.71,-14.93,;39.05,-22.64,;39.05,-24.17,;40.36,-21.88,;41.7,-22.65,;43.18,-22.32,;43.51,-23.86,;44.85,-24.63,;44.85,-26.17,;46.18,-23.86,;47.52,-24.63,;48.85,-23.86,;50.18,-24.63,;51.51,-23.86,;52.85,-24.63,;54.18,-23.86,;54.18,-22.32,;55.52,-24.63,;47.52,-26.17,;46.18,-26.95,;48.85,-26.95,;48.85,-28.49,;47.52,-29.25,;47.52,-30.79,;48.85,-31.57,;48.85,-33.11,;47.52,-33.88,;47.52,-35.42,;46.18,-33.11,;46.18,-31.57,;50.18,-29.25,;50.19,-30.79,;51.52,-28.48,;42.04,-24.17,;40.53,-24.53,;42.39,-25.67,)| Show InChI InChI=1S/C77H123N25O17/c1-11-39(5)59(100-70(116)54(32-44-21-25-47(106)26-22-44)96-67(113)55(33-45-36-86-37-90-45)97-64(110)49(91-42(8)104)16-13-27-87-74(80)81)71(117)98-56(35-58(78)107)68(114)95-53(30-38(3)4)69(115)101-60(40(6)12-2)72(118)102-61(41(7)103)73(119)93-51(18-15-29-89-76(84)85)66(112)99-57-34-48(77(57,9)10)63(109)92-50(17-14-28-88-75(82)83)65(111)94-52(62(79)108)31-43-19-23-46(105)24-20-43/h19-26,36-41,48-57,59-61,103,105-106H,11-18,27-35H2,1-10H3,(H2,78,107)(H2,79,108)(H,86,90)(H,91,104)(H,92,109)(H,93,119)(H,94,111)(H,95,114)(H,96,113)(H,97,110)(H,98,117)(H,99,112)(H,100,116)(H,101,115)(H,102,118)(H4,80,81,87)(H4,82,83,88)(H4,84,85,89)/t39-,40-,41+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,59-,60-,61-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Displacement of Cy5-pNPY from human Y5 receptor expressed in human HEC-1B cells after 90 to 120 mins by flow cytometry |
J Med Chem 56: 8422-31 (2013)
Article DOI: 10.1021/jm4008505
BindingDB Entry DOI: 10.7270/Q25X2BC9 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50441968
(CHEMBL2440189)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)C1(C)C |r,wU:93.94,89.91,87.88,30.39,8.17,2.2,45.46,61.62,76.77,wD:104.105,20.28,4.4,53.54,62.64,69.70,70.73,(16.35,-26.48,;16.35,-24.94,;17.69,-24.17,;19.02,-24.94,;17.69,-22.63,;16.35,-21.86,;15.02,-22.63,;15.02,-24.17,;13.68,-21.86,;13.68,-20.32,;15.02,-19.55,;16.34,-20.31,;17.69,-19.54,;17.68,-18,;19.01,-17.22,;16.33,-17.23,;15.02,-18.01,;12.35,-22.63,;11.02,-21.86,;11.02,-20.32,;9.69,-22.63,;9.69,-24.17,;11.02,-24.94,;12.44,-24.32,;13.47,-25.46,;12.7,-26.8,;11.18,-26.48,;8.35,-21.86,;7.02,-22.63,;7.02,-24.17,;5.68,-21.86,;5.68,-20.32,;7.02,-19.55,;7.02,-18.01,;8.35,-17.24,;8.35,-15.7,;7.02,-14.93,;9.69,-14.93,;4.35,-22.63,;3.01,-21.86,;1.67,-22.63,;3.01,-20.32,;19.02,-21.86,;19.02,-20.32,;20.36,-22.63,;21.7,-21.86,;21.7,-20.32,;23.03,-19.55,;24.36,-20.32,;23.03,-18.01,;23.03,-22.63,;23.03,-24.17,;24.36,-21.86,;25.69,-22.63,;25.69,-24.17,;27.03,-24.94,;27.03,-26.48,;28.36,-24.17,;27.03,-21.86,;27.03,-20.32,;28.36,-22.63,;29.7,-21.86,;29.7,-20.32,;31.03,-19.55,;28.36,-19.55,;28.36,-18.01,;31.03,-22.63,;31.03,-24.17,;32.37,-21.86,;33.7,-22.63,;33.7,-24.17,;32.37,-24.94,;35.04,-24.94,;35.04,-21.87,;35.04,-20.32,;36.38,-22.63,;37.7,-21.87,;37.7,-20.32,;39.04,-19.55,;39.04,-18.01,;40.37,-17.24,;40.37,-15.7,;39.04,-14.93,;41.71,-14.93,;39.05,-22.64,;39.05,-24.17,;40.36,-21.88,;41.7,-22.65,;43.18,-22.32,;43.51,-23.86,;44.85,-24.63,;44.85,-26.17,;46.18,-23.86,;47.52,-24.63,;48.85,-23.86,;50.18,-24.63,;51.51,-23.86,;52.85,-24.63,;54.18,-23.86,;54.18,-22.32,;55.52,-24.63,;47.52,-26.17,;46.18,-26.95,;48.85,-26.95,;48.85,-28.49,;47.52,-29.25,;47.52,-30.79,;48.85,-31.57,;48.85,-33.11,;47.52,-33.88,;47.52,-35.42,;46.18,-33.11,;46.18,-31.57,;50.18,-29.25,;50.19,-30.79,;51.52,-28.48,;42.04,-24.17,;40.53,-24.53,;42.39,-25.67,)| Show InChI InChI=1S/C77H123N25O17/c1-11-39(5)59(100-70(116)54(32-44-21-25-47(106)26-22-44)96-67(113)55(33-45-36-86-37-90-45)97-64(110)49(91-42(8)104)16-13-27-87-74(80)81)71(117)98-56(35-58(78)107)68(114)95-53(30-38(3)4)69(115)101-60(40(6)12-2)72(118)102-61(41(7)103)73(119)93-51(18-15-29-89-76(84)85)66(112)99-57-34-48(77(57,9)10)63(109)92-50(17-14-28-88-75(82)83)65(111)94-52(62(79)108)31-43-19-23-46(105)24-20-43/h19-26,36-41,48-57,59-61,103,105-106H,11-18,27-35H2,1-10H3,(H2,78,107)(H2,79,108)(H,86,90)(H,91,104)(H,92,109)(H,93,119)(H,94,111)(H,95,114)(H,96,113)(H,97,110)(H,98,117)(H,99,112)(H,100,116)(H,101,115)(H,102,118)(H4,80,81,87)(H4,82,83,88)(H4,84,85,89)/t39-,40-,41+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,59-,60-,61-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Displacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometry |
J Med Chem 56: 8422-31 (2013)
Article DOI: 10.1021/jm4008505
BindingDB Entry DOI: 10.7270/Q25X2BC9 |
More data for this
Ligand-Target Pair | |