Found 11 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity protein kinase CLK4
(Mus musculus) | BDBM50259572
(CHEMBL4076663)Show SMILES CC[C@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@H](CC)CO)nn12 |r| Show InChI InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France; Unité de Technologies Chimiques et Biologiques pour la Santé, Université Paris Descartes, UMR-S 1022 Inserm, 4 avenue
Curated by ChEMBL
| Assay Description Inhibition of [3H]WIN-35428 binding to dopamine transporter (DAT) |
Eur J Med Chem 125: 696-709 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.064 BindingDB Entry DOI: 10.7270/Q2M61NPG |
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK2
(Mus musculus) | BDBM50259572
(CHEMBL4076663)Show SMILES CC[C@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@H](CC)CO)nn12 |r| Show InChI InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France; Unité de Technologies Chimiques et Biologiques pour la Santé, Université Paris Descartes, UMR-S 1022 Inserm, 4 avenue
Curated by ChEMBL
| Assay Description Inhibition of GST tagged recombinant mouse CLK2 expressed in Escherichia coli using RS peptide as substrate after 30 mins by [gamma-33P]ATP based sci... |
Eur J Med Chem 125: 696-709 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.064 BindingDB Entry DOI: 10.7270/Q2M61NPG |
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Mus musculus) | BDBM50259572
(CHEMBL4076663)Show SMILES CC[C@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@H](CC)CO)nn12 |r| Show InChI InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France; Unité de Technologies Chimiques et Biologiques pour la Santé, Université Paris Descartes, UMR-S 1022 Inserm, 4 avenue
Curated by ChEMBL
| Assay Description Inhibition of GST tagged recombinant mouse CLK1 expressed in Escherichia coli using RS peptide as substrate after 30 mins by [gamma-33P]ATP based sci... |
Eur J Med Chem 125: 696-709 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.064 BindingDB Entry DOI: 10.7270/Q2M61NPG |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50259572
(CHEMBL4076663)Show SMILES CC[C@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@H](CC)CO)nn12 |r| Show InChI InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France; Unité de Technologies Chimiques et Biologiques pour la Santé, Université Paris Descartes, UMR-S 1022 Inserm, 4 avenue
Curated by ChEMBL
| Assay Description Inhibitory concentration against thrombin (FIIa); n=2 |
Eur J Med Chem 125: 696-709 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.064 BindingDB Entry DOI: 10.7270/Q2M61NPG |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human)) | BDBM50259572
(CHEMBL4076663)Show SMILES CC[C@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@H](CC)CO)nn12 |r| Show InChI InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France; Unité de Technologies Chimiques et Biologiques pour la Santé, Université Paris Descartes, UMR-S 1022 Inserm, 4 avenue
Curated by ChEMBL
| Assay Description Inhibitory concentration against thrombin (FIIa); n=2 |
Eur J Med Chem 125: 696-709 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.064 BindingDB Entry DOI: 10.7270/Q2M61NPG |
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK3
(Mus musculus) | BDBM50259572
(CHEMBL4076663)Show SMILES CC[C@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@H](CC)CO)nn12 |r| Show InChI InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France; Unité de Technologies Chimiques et Biologiques pour la Santé, Université Paris Descartes, UMR-S 1022 Inserm, 4 avenue
Curated by ChEMBL
| Assay Description Inhibition of GST tagged recombinant mouse CLK3 expressed in Escherichia coli using RS peptide as substrate after 30 mins by [gamma-33P]ATP based sci... |
Eur J Med Chem 125: 696-709 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.064 BindingDB Entry DOI: 10.7270/Q2M61NPG |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human)) | BDBM50259572
(CHEMBL4076663)Show SMILES CC[C@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@H](CC)CO)nn12 |r| Show InChI InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17-/m1/s1 | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France; Unité de Technologies Chimiques et Biologiques pour la Santé, Université Paris Descartes, UMR-S 1022 Inserm, 4 avenue
Curated by ChEMBL
| Assay Description Inhibition of GST tagged recombinant human DYRK2 expressed in Escherichia coli using using woodtide as substrate after 30 mins by [gamma-33P]ATP base... |
Eur J Med Chem 125: 696-709 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.064 BindingDB Entry DOI: 10.7270/Q2M61NPG |
More data for this Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50259572
(CHEMBL4076663)Show SMILES CC[C@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@H](CC)CO)nn12 |r| Show InChI InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France; Unité de Technologies Chimiques et Biologiques pour la Santé, Université Paris Descartes, UMR-S 1022 Inserm, 4 avenue
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CDK2/cyclin A after 30 mins by [gamma-33P]ATP based scintillation counting analysis |
Eur J Med Chem 125: 696-709 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.064 BindingDB Entry DOI: 10.7270/Q2M61NPG |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human)) | BDBM50259572
(CHEMBL4076663)Show SMILES CC[C@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@H](CC)CO)nn12 |r| Show InChI InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France; Unité de Technologies Chimiques et Biologiques pour la Santé, Université Paris Descartes, UMR-S 1022 Inserm, 4 avenue
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CDK5/p25 after 30 mins by [gamma-33P]ATP based scintillation counting analysis |
Eur J Med Chem 125: 696-709 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.064 BindingDB Entry DOI: 10.7270/Q2M61NPG |
More data for this Ligand-Target Pair | |
Cyclin-T1/Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM50259572
(CHEMBL4076663)Show SMILES CC[C@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@H](CC)CO)nn12 |r| Show InChI InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France; Unité de Technologies Chimiques et Biologiques pour la Santé, Université Paris Descartes, UMR-S 1022 Inserm, 4 avenue
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CDK9/cyclin T expressed in insect cells using CDK7/9-tide as substrate after 30 mins by [gamma-33P]ATP based scintill... |
Eur J Med Chem 125: 696-709 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.064 BindingDB Entry DOI: 10.7270/Q2M61NPG |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 3
(Homo sapiens (Human)) | BDBM50259572
(CHEMBL4076663)Show SMILES CC[C@H](CO)NC(=O)c1cccc(c1)-c1cnc2ccc(N[C@H](CC)CO)nn12 |r| Show InChI InChI=1S/C21H27N5O3/c1-3-16(12-27)23-19-8-9-20-22-11-18(26(20)25-19)14-6-5-7-15(10-14)21(29)24-17(4-2)13-28/h5-11,16-17,27-28H,3-4,12-13H2,1-2H3,(H,23,25)(H,24,29)/t16-,17-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France; Unité de Technologies Chimiques et Biologiques pour la Santé, Université Paris Descartes, UMR-S 1022 Inserm, 4 avenue
Curated by ChEMBL
| Assay Description Inhibition of GST tagged recombinant human DYRK3 expressed in Escherichia coli using woodtide as substrate after 30 mins by [gamma-33P]ATP based scin... |
Eur J Med Chem 125: 696-709 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.064 BindingDB Entry DOI: 10.7270/Q2M61NPG |
More data for this Ligand-Target Pair | |