Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cathepsin S
(Homo sapiens (Human)) | BDBM122522
(US8729061, 52)Show SMILES CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NCc1cccc2ccccc12 |r| Show InChI InChI=1S/C37H35Cl2N3O6S/c1-2-30(33(43)35(45)40-21-24-10-7-9-23-8-3-4-11-28(23)24)41-34(44)31-20-27(49(47,48)32-13-6-5-12-29(32)39)22-42(31)36(46)37(18-19-37)25-14-16-26(38)17-15-25/h3-17,27,30-31H,2,18-22H2,1H3,(H,40,45)(H,41,44)/t27-,30+,31+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.96 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh... |
US Patent US8729061 (2014)
BindingDB Entry DOI: 10.7270/Q2MS3RF6 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM122522
(US8729061, 52)Show SMILES CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NCc1cccc2ccccc12 |r| Show InChI InChI=1S/C37H35Cl2N3O6S/c1-2-30(33(43)35(45)40-21-24-10-7-9-23-8-3-4-11-28(23)24)41-34(44)31-20-27(49(47,48)32-13-6-5-12-29(32)39)22-42(31)36(46)37(18-19-37)25-14-16-26(38)17-15-25/h3-17,27,30-31H,2,18-22H2,1H3,(H,40,45)(H,41,44)/t27-,30+,31+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh... |
US Patent US8729061 (2014)
BindingDB Entry DOI: 10.7270/Q2MS3RF6 |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM122522
(US8729061, 52)Show SMILES CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NCc1cccc2ccccc12 |r| Show InChI InChI=1S/C37H35Cl2N3O6S/c1-2-30(33(43)35(45)40-21-24-10-7-9-23-8-3-4-11-28(23)24)41-34(44)31-20-27(49(47,48)32-13-6-5-12-29(32)39)22-42(31)36(46)37(18-19-37)25-14-16-26(38)17-15-25/h3-17,27,30-31H,2,18-22H2,1H3,(H,40,45)(H,41,44)/t27-,30+,31+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 317 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh... |
US Patent US8729061 (2014)
BindingDB Entry DOI: 10.7270/Q2MS3RF6 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM122522
(US8729061, 52)Show SMILES CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NCc1cccc2ccccc12 |r| Show InChI InChI=1S/C37H35Cl2N3O6S/c1-2-30(33(43)35(45)40-21-24-10-7-9-23-8-3-4-11-28(23)24)41-34(44)31-20-27(49(47,48)32-13-6-5-12-29(32)39)22-42(31)36(46)37(18-19-37)25-14-16-26(38)17-15-25/h3-17,27,30-31H,2,18-22H2,1H3,(H,40,45)(H,41,44)/t27-,30+,31+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 386 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh... |
US Patent US8729061 (2014)
BindingDB Entry DOI: 10.7270/Q2MS3RF6 |
More data for this
Ligand-Target Pair | |