Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cathepsin S
(Homo sapiens (Human)) | BDBM122503
(US8729061, 33)Show SMILES CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C33H33Cl2N3O6S/c1-2-26(29(39)31(41)36-19-21-8-4-3-5-9-21)37-30(40)27-18-24(45(43,44)28-11-7-6-10-25(28)35)20-38(27)32(42)33(16-17-33)22-12-14-23(34)15-13-22/h3-15,24,26-27H,2,16-20H2,1H3,(H,36,41)(H,37,40)/t24-,26+,27+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.11 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh... |
US Patent US8729061 (2014)
BindingDB Entry DOI: 10.7270/Q2MS3RF6 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM122503
(US8729061, 33)Show SMILES CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C33H33Cl2N3O6S/c1-2-26(29(39)31(41)36-19-21-8-4-3-5-9-21)37-30(40)27-18-24(45(43,44)28-11-7-6-10-25(28)35)20-38(27)32(42)33(16-17-33)22-12-14-23(34)15-13-22/h3-15,24,26-27H,2,16-20H2,1H3,(H,36,41)(H,37,40)/t24-,26+,27+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 13.6 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh... |
US Patent US8729061 (2014)
BindingDB Entry DOI: 10.7270/Q2MS3RF6 |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM122503
(US8729061, 33)Show SMILES CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C33H33Cl2N3O6S/c1-2-26(29(39)31(41)36-19-21-8-4-3-5-9-21)37-30(40)27-18-24(45(43,44)28-11-7-6-10-25(28)35)20-38(27)32(42)33(16-17-33)22-12-14-23(34)15-13-22/h3-15,24,26-27H,2,16-20H2,1H3,(H,36,41)(H,37,40)/t24-,26+,27+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 52.9 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh... |
US Patent US8729061 (2014)
BindingDB Entry DOI: 10.7270/Q2MS3RF6 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM122503
(US8729061, 33)Show SMILES CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C33H33Cl2N3O6S/c1-2-26(29(39)31(41)36-19-21-8-4-3-5-9-21)37-30(40)27-18-24(45(43,44)28-11-7-6-10-25(28)35)20-38(27)32(42)33(16-17-33)22-12-14-23(34)15-13-22/h3-15,24,26-27H,2,16-20H2,1H3,(H,36,41)(H,37,40)/t24-,26+,27+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 77 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh... |
US Patent US8729061 (2014)
BindingDB Entry DOI: 10.7270/Q2MS3RF6 |
More data for this
Ligand-Target Pair | |