Found 8 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Macrophage metalloelastase
(Homo sapiens (Human)) | BDBM120190
(US8691753, 38)Show SMILES CC[C@H](NC(=O)CCc1ccc(cc1)-c1ccsc1)C(=O)N[C@@H](CCC(O)=O)C(N)=O |r| Show InChI InChI=1S/C22H27N3O5S/c1-2-17(22(30)25-18(21(23)29)8-10-20(27)28)24-19(26)9-5-14-3-6-15(7-4-14)16-11-12-31-13-16/h3-4,6-7,11-13,17-18H,2,5,8-10H2,1H3,(H2,23,29)(H,24,26)(H,25,30)(H,27,28)/t17-,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Commissariat A l'Energie Atomique et Aux Energies Alternatives
US Patent
| Assay Description The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ... |
US Patent US8691753 (2014)
BindingDB Entry DOI: 10.7270/Q28P5Z5Q |
More data for this Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM120190
(US8691753, 38)Show SMILES CC[C@H](NC(=O)CCc1ccc(cc1)-c1ccsc1)C(=O)N[C@@H](CCC(O)=O)C(N)=O |r| Show InChI InChI=1S/C22H27N3O5S/c1-2-17(22(30)25-18(21(23)29)8-10-20(27)28)24-19(26)9-5-14-3-6-15(7-4-14)16-11-12-31-13-16/h3-4,6-7,11-13,17-18H,2,5,8-10H2,1H3,(H2,23,29)(H,24,26)(H,25,30)(H,27,28)/t17-,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Commissariat A l'Energie Atomique et Aux Energies Alternatives
US Patent
| Assay Description The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ... |
US Patent US8691753 (2014)
BindingDB Entry DOI: 10.7270/Q28P5Z5Q |
More data for this Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM120190
(US8691753, 38)Show SMILES CC[C@H](NC(=O)CCc1ccc(cc1)-c1ccsc1)C(=O)N[C@@H](CCC(O)=O)C(N)=O |r| Show InChI InChI=1S/C22H27N3O5S/c1-2-17(22(30)25-18(21(23)29)8-10-20(27)28)24-19(26)9-5-14-3-6-15(7-4-14)16-11-12-31-13-16/h3-4,6-7,11-13,17-18H,2,5,8-10H2,1H3,(H2,23,29)(H,24,26)(H,25,30)(H,27,28)/t17-,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 141 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Commissariat A l'Energie Atomique et Aux Energies Alternatives
US Patent
| Assay Description The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ... |
US Patent US8691753 (2014)
BindingDB Entry DOI: 10.7270/Q28P5Z5Q |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM120190
(US8691753, 38)Show SMILES CC[C@H](NC(=O)CCc1ccc(cc1)-c1ccsc1)C(=O)N[C@@H](CCC(O)=O)C(N)=O |r| Show InChI InChI=1S/C22H27N3O5S/c1-2-17(22(30)25-18(21(23)29)8-10-20(27)28)24-19(26)9-5-14-3-6-15(7-4-14)16-11-12-31-13-16/h3-4,6-7,11-13,17-18H,2,5,8-10H2,1H3,(H2,23,29)(H,24,26)(H,25,30)(H,27,28)/t17-,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 225 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Commissariat A l'Energie Atomique et Aux Energies Alternatives
US Patent
| Assay Description The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ... |
US Patent US8691753 (2014)
BindingDB Entry DOI: 10.7270/Q28P5Z5Q |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM120190
(US8691753, 38)Show SMILES CC[C@H](NC(=O)CCc1ccc(cc1)-c1ccsc1)C(=O)N[C@@H](CCC(O)=O)C(N)=O |r| Show InChI InChI=1S/C22H27N3O5S/c1-2-17(22(30)25-18(21(23)29)8-10-20(27)28)24-19(26)9-5-14-3-6-15(7-4-14)16-11-12-31-13-16/h3-4,6-7,11-13,17-18H,2,5,8-10H2,1H3,(H2,23,29)(H,24,26)(H,25,30)(H,27,28)/t17-,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 337 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Commissariat A l'Energie Atomique et Aux Energies Alternatives
US Patent
| Assay Description The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ... |
US Patent US8691753 (2014)
BindingDB Entry DOI: 10.7270/Q28P5Z5Q |
More data for this Ligand-Target Pair | |
Matrix metalloproteinase-14 [1-20,P8S]
(Homo sapiens (Human)) | BDBM120190
(US8691753, 38)Show SMILES CC[C@H](NC(=O)CCc1ccc(cc1)-c1ccsc1)C(=O)N[C@@H](CCC(O)=O)C(N)=O |r| Show InChI InChI=1S/C22H27N3O5S/c1-2-17(22(30)25-18(21(23)29)8-10-20(27)28)24-19(26)9-5-14-3-6-15(7-4-14)16-11-12-31-13-16/h3-4,6-7,11-13,17-18H,2,5,8-10H2,1H3,(H2,23,29)(H,24,26)(H,25,30)(H,27,28)/t17-,18-/m0/s1 | MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Commissariat A l'Energie Atomique et Aux Energies Alternatives
US Patent
| Assay Description The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ... |
US Patent US8691753 (2014)
BindingDB Entry DOI: 10.7270/Q28P5Z5Q |
More data for this Ligand-Target Pair | |
Stromelysin-2
(Homo sapiens (Human)) | BDBM120190
(US8691753, 38)Show SMILES CC[C@H](NC(=O)CCc1ccc(cc1)-c1ccsc1)C(=O)N[C@@H](CCC(O)=O)C(N)=O |r| Show InChI InChI=1S/C22H27N3O5S/c1-2-17(22(30)25-18(21(23)29)8-10-20(27)28)24-19(26)9-5-14-3-6-15(7-4-14)16-11-12-31-13-16/h3-4,6-7,11-13,17-18H,2,5,8-10H2,1H3,(H2,23,29)(H,24,26)(H,25,30)(H,27,28)/t17-,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 446 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Commissariat A l'Energie Atomique et Aux Energies Alternatives
US Patent
| Assay Description The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ... |
US Patent US8691753 (2014)
BindingDB Entry DOI: 10.7270/Q28P5Z5Q |
More data for this Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM120190
(US8691753, 38)Show SMILES CC[C@H](NC(=O)CCc1ccc(cc1)-c1ccsc1)C(=O)N[C@@H](CCC(O)=O)C(N)=O |r| Show InChI InChI=1S/C22H27N3O5S/c1-2-17(22(30)25-18(21(23)29)8-10-20(27)28)24-19(26)9-5-14-3-6-15(7-4-14)16-11-12-31-13-16/h3-4,6-7,11-13,17-18H,2,5,8-10H2,1H3,(H2,23,29)(H,24,26)(H,25,30)(H,27,28)/t17-,18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 532 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Commissariat A l'Energie Atomique et Aux Energies Alternatives
US Patent
| Assay Description The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ... |
US Patent US8691753 (2014)
BindingDB Entry DOI: 10.7270/Q28P5Z5Q |
More data for this Ligand-Target Pair | |