Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM230025
(US9556135, 193)Show SMILES CC1(C)C(N)=N[C@@](CF)(CS1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F |r,c:4| Show InChI InChI=1S/C19H19ClF2N4O3S/c1-18(2)17(23)26-19(9-21,10-30(18,28)29)13-7-12(4-5-14(13)22)25-16(27)15-6-3-11(20)8-24-15/h3-8H,9-10H2,1-2H3,(H2,23,26)(H,25,27)/t19-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.760 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
US Patent
| Assay Description Several animal models, including mouse, rat, dog, and monkey, may be used to screen for inhibition of beta-secretase activity in vivo following admin... |
US Patent US9556135 (2017)
BindingDB Entry DOI: 10.7270/Q2X0691F |
More data for this Ligand-Target Pair | |
Cathepsin D
(Homo sapiens (Human)) | BDBM230025
(US9556135, 193)Show SMILES CC1(C)C(N)=N[C@@](CF)(CS1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F |r,c:4| Show InChI InChI=1S/C19H19ClF2N4O3S/c1-18(2)17(23)26-19(9-21,10-30(18,28)29)13-7-12(4-5-14(13)22)25-16(27)15-6-3-11(20)8-24-15/h3-8H,9-10H2,1-2H3,(H2,23,26)(H,25,27)/t19-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.28E+5 | n/a | n/a | n/a | n/a | 3.5 | n/a |
Amgen, Inc.
US Patent
| Assay Description Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ... |
US Patent US9556135 (2017)
BindingDB Entry DOI: 10.7270/Q2X0691F |
More data for this Ligand-Target Pair | |