Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 2
(Homo sapiens (Human)) | BDBM448220
(US10689401, EX 22 | US11008338, Example 22)Show SMILES CC1(C)C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(OCC2CC2)ccc1F |r| Show InChI InChI=1S/C21H29FN2O4S/c1-19(2)10-17-21(12-28-19,24-18(23)20(3,4)29(17,25)26)15-9-14(7-8-16(15)22)27-11-13-5-6-13/h7-9,13,17H,5-6,10-12H2,1-4H3,(H2,23,24)/t17-,21-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| 35.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
BACE-2: Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY... |
US Patent US10689401 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DS6 |
More data for this
Ligand-Target Pair | |
Beta-secretase 2
(Homo sapiens (Human)) | BDBM448220
(US10689401, EX 22 | US11008338, Example 22)Show SMILES CC1(C)C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(OCC2CC2)ccc1F |r| Show InChI InChI=1S/C21H29FN2O4S/c1-19(2)10-17-21(12-28-19,24-18(23)20(3,4)29(17,25)26)15-9-14(7-8-16(15)22)27-11-13-5-6-13/h7-9,13,17H,5-6,10-12H2,1-4H3,(H2,23,24)/t17-,21-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 35.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
BACE2: Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7... |
US Patent US11008338 (2021)
BindingDB Entry DOI: 10.7270/Q2RF5Z46 |
More data for this
Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM448220
(US10689401, EX 22 | US11008338, Example 22)Show SMILES CC1(C)C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(OCC2CC2)ccc1F |r| Show InChI InChI=1S/C21H29FN2O4S/c1-19(2)10-17-21(12-28-19,24-18(23)20(3,4)29(17,25)26)15-9-14(7-8-16(15)22)27-11-13-5-6-13/h7-9,13,17H,5-6,10-12H2,1-4H3,(H2,23,24)/t17-,21-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
BACE1: A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This a... |
US Patent US11008338 (2021)
BindingDB Entry DOI: 10.7270/Q2RF5Z46 |
More data for this
Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM448220
(US10689401, EX 22 | US11008338, Example 22)Show SMILES CC1(C)C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(OCC2CC2)ccc1F |r| Show InChI InChI=1S/C21H29FN2O4S/c1-19(2)10-17-21(12-28-19,24-18(23)20(3,4)29(17,25)26)15-9-14(7-8-16(15)22)27-11-13-5-6-13/h7-9,13,17H,5-6,10-12H2,1-4H3,(H2,23,24)/t17-,21-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
BACE1: A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This a... |
US Patent US10689401 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DS6 |
More data for this
Ligand-Target Pair | |