Found 7 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Voltage-dependent T-type calcium channel subunit alpha-1H
(Homo sapiens (Human)) | BDBM164339
(US9688615, 150)Show SMILES CC1(C)NCCN(Cc2nc3cc(c(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1=O Show InChI InChI=1S/C16H16F6N4O/c1-14(2)13(27)26(4-3-23-14)7-12-24-10-5-8(15(17,18)19)9(16(20,21)22)6-11(10)25-12/h5-6,23H,3-4,7H2,1-2H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 8.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC
US Patent
| Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in... |
US Patent US9688615 (2017)
BindingDB Entry DOI: 10.7270/Q27S7KXH |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Homo sapiens (Human)) | BDBM164339
(US9688615, 150)Show SMILES CC1(C)NCCN(Cc2nc3cc(c(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1=O Show InChI InChI=1S/C16H16F6N4O/c1-14(2)13(27)26(4-3-23-14)7-12-24-10-5-8(15(17,18)19)9(16(20,21)22)6-11(10)25-12/h5-6,23H,3-4,7H2,1-2H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC
US Patent
| Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in... |
US Patent US9688615 (2017)
BindingDB Entry DOI: 10.7270/Q27S7KXH |
More data for this Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1G
(Homo sapiens (Human)) | BDBM164339
(US9688615, 150)Show SMILES CC1(C)NCCN(Cc2nc3cc(c(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1=O Show InChI InChI=1S/C16H16F6N4O/c1-14(2)13(27)26(4-3-23-14)7-12-24-10-5-8(15(17,18)19)9(16(20,21)22)6-11(10)25-12/h5-6,23H,3-4,7H2,1-2H3,(H,24,25) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC
US Patent
| Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in... |
US Patent US9688615 (2017)
BindingDB Entry DOI: 10.7270/Q27S7KXH |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human)) | BDBM164339
(US9688615, 150)Show SMILES CC1(C)NCCN(Cc2nc3cc(c(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1=O Show InChI InChI=1S/C16H16F6N4O/c1-14(2)13(27)26(4-3-23-14)7-12-24-10-5-8(15(17,18)19)9(16(20,21)22)6-11(10)25-12/h5-6,23H,3-4,7H2,1-2H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
SRMLSC
US Patent
| Assay Description To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b... |
US Patent US9688615 (2017)
BindingDB Entry DOI: 10.7270/Q27S7KXH |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human)) | BDBM164339
(US9688615, 150)Show SMILES CC1(C)NCCN(Cc2nc3cc(c(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1=O Show InChI InChI=1S/C16H16F6N4O/c1-14(2)13(27)26(4-3-23-14)7-12-24-10-5-8(15(17,18)19)9(16(20,21)22)6-11(10)25-12/h5-6,23H,3-4,7H2,1-2H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
SRMLSC
US Patent
| Assay Description To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b... |
US Patent US9688615 (2017)
BindingDB Entry DOI: 10.7270/Q27S7KXH |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Homo sapiens (Human)) | BDBM164339
(US9688615, 150)Show SMILES CC1(C)NCCN(Cc2nc3cc(c(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1=O Show InChI InChI=1S/C16H16F6N4O/c1-14(2)13(27)26(4-3-23-14)7-12-24-10-5-8(15(17,18)19)9(16(20,21)22)6-11(10)25-12/h5-6,23H,3-4,7H2,1-2H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC
US Patent
| Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in... |
US Patent US9688615 (2017)
BindingDB Entry DOI: 10.7270/Q27S7KXH |
More data for this Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1H
(Homo sapiens (Human)) | BDBM164339
(US9688615, 150)Show SMILES CC1(C)NCCN(Cc2nc3cc(c(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1=O Show InChI InChI=1S/C16H16F6N4O/c1-14(2)13(27)26(4-3-23-14)7-12-24-10-5-8(15(17,18)19)9(16(20,21)22)6-11(10)25-12/h5-6,23H,3-4,7H2,1-2H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC
US Patent
| Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in... |
US Patent US9688615 (2017)
BindingDB Entry DOI: 10.7270/Q27S7KXH |
More data for this Ligand-Target Pair | |