Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Endothelial lipase
(Homo sapiens (Human)) | BDBM50364302
(CHEMBL1952314)Show SMILES CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1cccc(CCC(O)=O)c1 Show InChI InChI=1S/C21H25BO4/c1-20(2)21(3,4)26-22(25-20)18-11-9-16(10-12-18)17-7-5-6-15(14-17)8-13-19(23)24/h5-7,9-12,14H,8,13H2,1-4H3,(H,23,24) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tufts University School of Medicine
Curated by ChEMBL
| Assay Description
Inhibition of human endothelial lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay |
Bioorg Med Chem Lett 22: 1397-401 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.043
BindingDB Entry DOI: 10.7270/Q28G8M5N |
More data for this
Ligand-Target Pair | |
Lipoprotein lipase
(Homo sapiens (Human)) | BDBM50364302
(CHEMBL1952314)Show SMILES CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1cccc(CCC(O)=O)c1 Show InChI InChI=1S/C21H25BO4/c1-20(2)21(3,4)26-22(25-20)18-11-9-16(10-12-18)17-7-5-6-15(14-17)8-13-19(23)24/h5-7,9-12,14H,8,13H2,1-4H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tufts University School of Medicine
Curated by ChEMBL
| Assay Description
Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay |
Bioorg Med Chem Lett 22: 1397-401 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.043
BindingDB Entry DOI: 10.7270/Q28G8M5N |
More data for this
Ligand-Target Pair | |
Endothelial lipase
(Homo sapiens (Human)) | BDBM50364302
(CHEMBL1952314)Show SMILES CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1cccc(CCC(O)=O)c1 Show InChI InChI=1S/C21H25BO4/c1-20(2)21(3,4)26-22(25-20)18-11-9-16(10-12-18)17-7-5-6-15(14-17)8-13-19(23)24/h5-7,9-12,14H,8,13H2,1-4H3,(H,23,24) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tufts University School of Medicine
Curated by ChEMBL
| Assay Description
Inhibition of human endothelial lipase overexpressed in HUVEC cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substr... |
Bioorg Med Chem Lett 22: 1397-401 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.043
BindingDB Entry DOI: 10.7270/Q28G8M5N |
More data for this
Ligand-Target Pair | |
Lipoprotein lipase
(Homo sapiens (Human)) | BDBM50364302
(CHEMBL1952314)Show SMILES CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1cccc(CCC(O)=O)c1 Show InChI InChI=1S/C21H25BO4/c1-20(2)21(3,4)26-22(25-20)18-11-9-16(10-12-18)17-7-5-6-15(14-17)8-13-19(23)24/h5-7,9-12,14H,8,13H2,1-4H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tufts University School of Medicine
Curated by ChEMBL
| Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate... |
Bioorg Med Chem Lett 22: 1397-401 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.043
BindingDB Entry DOI: 10.7270/Q28G8M5N |
More data for this
Ligand-Target Pair | |