Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 366.4 BDBM301638

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM301638 (US10131675, Example 124) Show SMILES CC1(C)OCCn2c1nc1c(NC3CCC3)nc(nc21)-c1cnc(N)nc1 Show InChI InChI=1S/C18H22N8O/c1-18(2)16-23-12-14(22-11-4-3-5-11)24-13(10-8-20-17(19)21-9-10)25-15(12)26(16)6-7-27-18/h8-9,11H,3-7H2,1-2H3,(H2,19,20,21)(H,22,24,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	73.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...				US Patent US10131675 (2018) BindingDB Entry DOI: 10.7270/Q21G0P92
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