Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin E synthase
(Homo sapiens (Human)) | BDBM50249003
(CHEMBL4081601)Show SMILES CC1(C)Oc2cc(ccc2-c2nc([nH]c12)-c1c(cccc1C#N)C#N)C#Cc1cc(Cl)ccc1Cl Show InChI InChI=1S/C28H16Cl2N4O/c1-28(2)26-25(33-27(34-26)24-18(14-31)4-3-5-19(24)15-32)21-10-7-16(12-23(21)35-28)6-8-17-13-20(29)9-11-22(17)30/h3-5,7,9-13H,1-2H3,(H,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human mPGES-1 expressed in CHO cells assessed as reduction in PGE2 formation using PGH2 a substrate preincubated for 10 min... |
Bioorg Med Chem Lett 27: 2594-2601 (2017)
Article DOI: 10.1016/j.bmcl.2017.03.068
BindingDB Entry DOI: 10.7270/Q24B33Q3 |
More data for this
Ligand-Target Pair | |
Prostaglandin E synthase
(Homo sapiens (Human)) | BDBM50249003
(CHEMBL4081601)Show SMILES CC1(C)Oc2cc(ccc2-c2nc([nH]c12)-c1c(cccc1C#N)C#N)C#Cc1cc(Cl)ccc1Cl Show InChI InChI=1S/C28H16Cl2N4O/c1-28(2)26-25(33-27(34-26)24-18(14-31)4-3-5-19(24)15-32)21-10-7-16(12-23(21)35-28)6-8-17-13-20(29)9-11-22(17)30/h3-5,7,9-13H,1-2H3,(H,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description
Inhibition of mPGES-1 in human A549 cells assessed as decrease in IL1beta induced PGE2 release preincubated for 30 mins followed by IL-1beta addition... |
Bioorg Med Chem Lett 27: 2594-2601 (2017)
Article DOI: 10.1016/j.bmcl.2017.03.068
BindingDB Entry DOI: 10.7270/Q24B33Q3 |
More data for this
Ligand-Target Pair | |