Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 431.5 BDBM178929

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM178929 (US9126931, 74) Show SMILES CC1(C)c2[nH]c3cc(ccc3c2C(=O)c2ccc(OC3CCN(CCF)CC3)cc12)C#N Show InChI InChI=1S/C26H26FN3O2/c1-26(2)21-14-18(32-17-7-10-30(11-8-17)12-9-27)4-6-19(21)24(31)23-20-5-3-16(15-28)13-22(20)29-25(23)26/h3-6,13-14,17,29H,7-12H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.46	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description ALK-inhibiting activity was measured by following an activity of inhibiting phosphorylation by biotinylated peptide (EGPWLEEEEEAYGWMDF). For the dete...				US Patent US9126931 (2015) BindingDB Entry DOI: 10.7270/Q22J69N8
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