Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Voltage-dependent T-type calcium channel subunit alpha-1G
(Homo sapiens (Human)) | BDBM50452287
(CHEMBL4206219)Show SMILES CC1(COc2ccc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)cc2)COC1 Show InChI InChI=1S/C23H23F2N3O3/c1-23(13-30-14-23)15-31-18-5-2-16(3-6-18)11-22(29)26-21-8-9-28(27-21)12-17-4-7-19(24)20(25)10-17/h2-10H,11-15H2,1H3,(H,26,27,29) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Idorsia Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Cav3.1 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ... |
J Med Chem 60: 9769-9789 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01236
BindingDB Entry DOI: 10.7270/Q24M9745 |
More data for this
Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1I
(Homo sapiens (Human)) | BDBM50452287
(CHEMBL4206219)Show SMILES CC1(COc2ccc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)cc2)COC1 Show InChI InChI=1S/C23H23F2N3O3/c1-23(13-30-14-23)15-31-18-5-2-16(3-6-18)11-22(29)26-21-8-9-28(27-21)12-17-4-7-19(24)20(25)10-17/h2-10H,11-15H2,1H3,(H,26,27,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Idorsia Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Cav3.3 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ... |
J Med Chem 60: 9769-9789 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01236
BindingDB Entry DOI: 10.7270/Q24M9745 |
More data for this
Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1H
(Homo sapiens (Human)) | BDBM50452287
(CHEMBL4206219)Show SMILES CC1(COc2ccc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)cc2)COC1 Show InChI InChI=1S/C23H23F2N3O3/c1-23(13-30-14-23)15-31-18-5-2-16(3-6-18)11-22(29)26-21-8-9-28(27-21)12-17-4-7-19(24)20(25)10-17/h2-10H,11-15H2,1H3,(H,26,27,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Idorsia Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ... |
J Med Chem 60: 9769-9789 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01236
BindingDB Entry DOI: 10.7270/Q24M9745 |
More data for this
Ligand-Target Pair | |