Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Beta-lactamase TEM
(Escherichia coli) | BDBM467000
(2-(((2S,5R)-2-carbamoyl-4-methyl-7-oxo-1,6-diazabi...)Show SMILES CC1=C[C@H](N2C[C@@H]1N(OC(F)(F)C(O)=O)C2=O)C(N)=O |r,t:1| Show InChI InChI=1S/C10H11F2N3O5/c1-4-2-5(7(13)16)14-3-6(4)15(9(14)19)20-10(11,12)8(17)18/h2,5-6H,3H2,1H3,(H2,13,16)(H,17,18)/t5-,6?/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
Entasis Therapeutics Limited
US Patent
| Assay Description A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit... |
US Patent US10800778 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V9G |
More data for this Ligand-Target Pair | |
Beta-lactamase
(Klebsiella pneumoniae) | BDBM467000
(2-(((2S,5R)-2-carbamoyl-4-methyl-7-oxo-1,6-diazabi...)Show SMILES CC1=C[C@H](N2C[C@@H]1N(OC(F)(F)C(O)=O)C2=O)C(N)=O |r,t:1| Show InChI InChI=1S/C10H11F2N3O5/c1-4-2-5(7(13)16)14-3-6(4)15(9(14)19)20-10(11,12)8(17)18/h2,5-6H,3H2,1H3,(H2,13,16)(H,17,18)/t5-,6?/m0/s1 | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Entasis Therapeutics Limited
US Patent
| Assay Description A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit... |
US Patent US10800778 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V9G |
More data for this Ligand-Target Pair | |
Beta-lactamase
(Escherichia coli) | BDBM467000
(2-(((2S,5R)-2-carbamoyl-4-methyl-7-oxo-1,6-diazabi...)Show SMILES CC1=C[C@H](N2C[C@@H]1N(OC(F)(F)C(O)=O)C2=O)C(N)=O |r,t:1| Show InChI InChI=1S/C10H11F2N3O5/c1-4-2-5(7(13)16)14-3-6(4)15(9(14)19)20-10(11,12)8(17)18/h2,5-6H,3H2,1H3,(H2,13,16)(H,17,18)/t5-,6?/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Entasis Therapeutics Limited
US Patent
| Assay Description A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit... |
US Patent US10800778 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V9G |
More data for this Ligand-Target Pair | |