Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50254307
(CHEMBL4066409)Show SMILES CCC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CO)NC(C)=O)C(=O)NC(CC1CCCCC1)C(=O)NC(CC1CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC(CC1CCCCC1)C(N)=O |r| Show InChI InChI=1S/C83H148N26O19/c1-10-51(97-68(117)52(29-20-34-93-80(87)88)99-72(121)57(37-44(2)3)103-76(125)62(43-110)96-47(7)112)67(116)105-59(40-49-25-16-12-17-26-49)73(122)106-60(41-50-27-18-13-19-28-50)74(123)107-61(42-64(85)114)75(124)104-58(38-45(4)5)77(126)109-83(8,9)79(128)108-65(46(6)111)78(127)101-54(31-22-36-95-82(91)92)69(118)100-55(32-33-63(84)113)71(120)98-53(30-21-35-94-81(89)90)70(119)102-56(66(86)115)39-48-23-14-11-15-24-48/h44-46,48-62,65,110-111H,10-43H2,1-9H3,(H2,84,113)(H2,85,114)(H2,86,115)(H,96,112)(H,97,117)(H,98,120)(H,99,121)(H,100,118)(H,101,127)(H,102,119)(H,103,125)(H,104,124)(H,105,116)(H,106,122)(H,107,123)(H,108,128)(H,109,126)(H4,87,88,93)(H4,89,90,94)(H4,91,92,95)/t46-,51?,52+,53+,54+,55+,56?,57-,58+,59?,60?,61+,62-,65+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd., Fujisawa 251-8555, Japan.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY from human Y2R expressed in CHO cell membranes after 60 mins by liquid scintillation method |
ACS Med Chem Lett 8: 628-631 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00047
BindingDB Entry DOI: 10.7270/Q2W37ZS8 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50254307
(CHEMBL4066409)Show SMILES CCC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CO)NC(C)=O)C(=O)NC(CC1CCCCC1)C(=O)NC(CC1CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC(CC1CCCCC1)C(N)=O |r| Show InChI InChI=1S/C83H148N26O19/c1-10-51(97-68(117)52(29-20-34-93-80(87)88)99-72(121)57(37-44(2)3)103-76(125)62(43-110)96-47(7)112)67(116)105-59(40-49-25-16-12-17-26-49)73(122)106-60(41-50-27-18-13-19-28-50)74(123)107-61(42-64(85)114)75(124)104-58(38-45(4)5)77(126)109-83(8,9)79(128)108-65(46(6)111)78(127)101-54(31-22-36-95-82(91)92)69(118)100-55(32-33-63(84)113)71(120)98-53(30-21-35-94-81(89)90)70(119)102-56(66(86)115)39-48-23-14-11-15-24-48/h44-46,48-62,65,110-111H,10-43H2,1-9H3,(H2,84,113)(H2,85,114)(H2,86,115)(H,96,112)(H,97,117)(H,98,120)(H,99,121)(H,100,118)(H,101,127)(H,102,119)(H,103,125)(H,104,124)(H,105,116)(H,106,122)(H,107,123)(H,108,128)(H,109,126)(H4,87,88,93)(H4,89,90,94)(H4,91,92,95)/t46-,51?,52+,53+,54+,55+,56?,57-,58+,59?,60?,61+,62-,65+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd., Fujisawa 251-8555, Japan.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY from human Y2R expressed in CHO cell membranes after 60 mins by liquid scintillation method |
ACS Med Chem Lett 8: 628-631 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00047
BindingDB Entry DOI: 10.7270/Q2W37ZS8 |
More data for this
Ligand-Target Pair | |