Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50254347
(CHEMBL4076542)Show SMILES CCC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)NC(CC1CCCCC1)C(=O)NC(CC1CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC(CC1CCCCC1)C(N)=O |r| Show InChI InChI=1S/C80H143N25O17/c1-10-50(94-66(112)51(29-20-34-90-77(84)85)96-70(116)56(37-43(2)3)93-46(7)107)65(111)101-58(40-48-25-16-12-17-26-48)71(117)102-59(41-49-27-18-13-19-28-49)72(118)103-60(42-62(82)109)73(119)100-57(38-44(4)5)74(120)105-80(8,9)76(122)104-63(45(6)106)75(121)98-53(31-22-36-92-79(88)89)67(113)97-54(32-33-61(81)108)69(115)95-52(30-21-35-91-78(86)87)68(114)99-55(64(83)110)39-47-23-14-11-15-24-47/h43-45,47-60,63,106H,10-42H2,1-9H3,(H2,81,108)(H2,82,109)(H2,83,110)(H,93,107)(H,94,112)(H,95,115)(H,96,116)(H,97,113)(H,98,121)(H,99,114)(H,100,119)(H,101,111)(H,102,117)(H,103,118)(H,104,122)(H,105,120)(H4,84,85,90)(H4,86,87,91)(H4,88,89,92)/t45-,50?,51+,52+,53+,54+,55?,56+,57+,58?,59?,60+,63+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd., Fujisawa 251-8555, Japan.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY from human Y2R expressed in CHO cell membranes after 60 mins by liquid scintillation method |
ACS Med Chem Lett 8: 628-631 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00047
BindingDB Entry DOI: 10.7270/Q2W37ZS8 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50254347
(CHEMBL4076542)Show SMILES CCC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)NC(CC1CCCCC1)C(=O)NC(CC1CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC(CC1CCCCC1)C(N)=O |r| Show InChI InChI=1S/C80H143N25O17/c1-10-50(94-66(112)51(29-20-34-90-77(84)85)96-70(116)56(37-43(2)3)93-46(7)107)65(111)101-58(40-48-25-16-12-17-26-48)71(117)102-59(41-49-27-18-13-19-28-49)72(118)103-60(42-62(82)109)73(119)100-57(38-44(4)5)74(120)105-80(8,9)76(122)104-63(45(6)106)75(121)98-53(31-22-36-92-79(88)89)67(113)97-54(32-33-61(81)108)69(115)95-52(30-21-35-91-78(86)87)68(114)99-55(64(83)110)39-47-23-14-11-15-24-47/h43-45,47-60,63,106H,10-42H2,1-9H3,(H2,81,108)(H2,82,109)(H2,83,110)(H,93,107)(H,94,112)(H,95,115)(H,96,116)(H,97,113)(H,98,121)(H,99,114)(H,100,119)(H,101,111)(H,102,117)(H,103,118)(H,104,122)(H,105,120)(H4,84,85,90)(H4,86,87,91)(H4,88,89,92)/t45-,50?,51+,52+,53+,54+,55?,56+,57+,58?,59?,60+,63+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 6.40 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd., Fujisawa 251-8555, Japan.
Curated by ChEMBL
| Assay Description
Agonist activity at human Y2R expressed in CHO cell membranes assessed as [35S]GTPgammaS binding after 120 mins by liquid scintillation method |
ACS Med Chem Lett 8: 628-631 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00047
BindingDB Entry DOI: 10.7270/Q2W37ZS8 |
More data for this
Ligand-Target Pair | |