Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin E synthase
(Homo sapiens (Human)) | BDBM50351422
(CHEMBL1819394)Show SMILES CCCCC(Cc1ccc(OCCc2ccccc2)c(OCCc2ccccc2)c1)C(O)=O Show InChI InChI=1S/C29H34O4/c1-2-3-14-26(29(30)31)21-25-15-16-27(32-19-17-23-10-6-4-7-11-23)28(22-25)33-20-18-24-12-8-5-9-13-24/h4-13,15-16,22,26H,2-3,14,17-21H2,1H3,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ZAFES/LiFF/Goethe-University Frankfurt
Curated by ChEMBL
| Assay Description
Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an... |
J Med Chem 54: 4490-507 (2011)
Article DOI: 10.1021/jm200092b
BindingDB Entry DOI: 10.7270/Q2XG9S8B |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50351422
(CHEMBL1819394)Show SMILES CCCCC(Cc1ccc(OCCc2ccccc2)c(OCCc2ccccc2)c1)C(O)=O Show InChI InChI=1S/C29H34O4/c1-2-3-14-26(29(30)31)21-25-15-16-27(32-19-17-23-10-6-4-7-11-23)28(22-25)33-20-18-24-12-8-5-9-13-24/h4-13,15-16,22,26H,2-3,14,17-21H2,1H3,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ZAFES/LiFF/Goethe-University Frankfurt
Curated by ChEMBL
| Assay Description
Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challenge |
J Med Chem 54: 4490-507 (2011)
Article DOI: 10.1021/jm200092b
BindingDB Entry DOI: 10.7270/Q2XG9S8B |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50351422
(CHEMBL1819394)Show SMILES CCCCC(Cc1ccc(OCCc2ccccc2)c(OCCc2ccccc2)c1)C(O)=O Show InChI InChI=1S/C29H34O4/c1-2-3-14-26(29(30)31)21-25-15-16-27(32-19-17-23-10-6-4-7-11-23)28(22-25)33-20-18-24-12-8-5-9-13-24/h4-13,15-16,22,26H,2-3,14,17-21H2,1H3,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ZAFES/LiFF/Goethe-University Frankfurt
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant 5-lipoxygenase-mediated product formation from arachidonic acid after 5 to 10 mins by HPLC analysis |
J Med Chem 54: 4490-507 (2011)
Article DOI: 10.1021/jm200092b
BindingDB Entry DOI: 10.7270/Q2XG9S8B |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50351422
(CHEMBL1819394)Show SMILES CCCCC(Cc1ccc(OCCc2ccccc2)c(OCCc2ccccc2)c1)C(O)=O Show InChI InChI=1S/C29H34O4/c1-2-3-14-26(29(30)31)21-25-15-16-27(32-19-17-23-10-6-4-7-11-23)28(22-25)33-20-18-24-12-8-5-9-13-24/h4-13,15-16,22,26H,2-3,14,17-21H2,1H3,(H,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt
Curated by ChEMBL
| Assay Description
Modulation of human PPARgamma-LBD expressed in african green monkey COS7 cells co-transfected with Gal4 assessed as activation of transactivation act... |
Bioorg Med Chem 19: 5372-82 (2011)
Article DOI: 10.1016/j.bmc.2011.08.003
BindingDB Entry DOI: 10.7270/Q2JQ11D0 |
More data for this
Ligand-Target Pair | |