Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Acid ceramidase
(Homo sapiens (Human)) | BDBM50431262
(CHEMBL2333042 | US9428465, 5)Show InChI InChI=1S/C11H16BrN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | 4.5 | n/a |
Fondazione Istituto Italiano Di Technologia
US Patent
| Assay Description A hAC protein preparation (10 μg) was preincubated with inhibitors (final DMSO concentration 1%) in assay buffer (100 mM sodium phosphate, 0.1% ... |
US Patent US9428465 (2016)
BindingDB Entry DOI: 10.7270/Q26972GB |
More data for this Ligand-Target Pair | |
Acid ceramidase
(Rattus norvegicus (Rat)) | BDBM50431262
(CHEMBL2333042 | US9428465, 5)Show InChI InChI=1S/C11H16BrN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Fondazione Istituto Italiano di Tecnologia
Curated by ChEMBL
| Assay Description Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub... |
J Med Chem 56: 3518-30 (2013)
Article DOI: 10.1021/jm301879g BindingDB Entry DOI: 10.7270/Q27D2WH5 |
More data for this Ligand-Target Pair | |
Acid ceramidase
(Rattus norvegicus (Rat)) | BDBM50431262
(CHEMBL2333042 | US9428465, 5)Show InChI InChI=1S/C11H16BrN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | 4.5 | n/a |
Fondazione Istituto Italiano Di Technologia
US Patent
| Assay Description r-AC protein samples were pre-incubated with various concentrations of test compounds or vehicle control in 100 mM NaH2PO4/citrate buffer pH 4.5, 0.1... |
US Patent US9428465 (2016)
BindingDB Entry DOI: 10.7270/Q26972GB |
More data for this Ligand-Target Pair | |