Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 472.4 BDBM176300

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM176300 (US9688696, 15) Show SMILES CCCCn1nccc1-c1ccc(cc1)N1CCN(CC1)C(=O)Nc1c(Cl)cccc1Cl Show InChI InChI=1S/C24H27Cl2N5O/c1-2-3-13-31-22(11-12-27-31)18-7-9-19(10-8-18)29-14-16-30(17-15-29)24(32)28-23-20(25)5-4-6-21(23)26/h4-12H,2-3,13-17H2,1H3,(H,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	7.4	25
Janssen Pharmaceutica N.V. US Patent					Assay Description DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...				US Patent US9688696 (2017) BindingDB Entry DOI: 10.7270/Q24X55ZP
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