Found 7 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50441103
(CHEMBL2430577)Show SMILES CCCOc1c2Cc3cccc(Cc4cccc(Cc5cc(cc(Cc1ccc2)c5O)C(O)(P(O)(O)=O)P(O)(O)=O)c4OCCC)c3O Show InChI InChI=1S/C35H40O11P2/c1-3-14-45-33-24-10-6-12-26(33)18-28-20-30(35(38,47(39,40)41)48(42,43)44)21-29(32(28)37)19-27-13-7-11-25(34(27)46-15-4-2)17-23-9-5-8-22(16-24)31(23)36/h5-13,20-21,36-38H,3-4,14-19H2,1-2H3,(H2,39,40,41)(H2,42,43,44) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Academy of Sciences of Ukraine
Curated by ChEMBL
| Assay Description Reversible inhibition of recombinant full length PTP1B (unknown origin) assessed as p-nitrophenyl phosphate conversion to p-nitrophenol after 10 mins... |
Bioorg Med Chem Lett 23: 5619-23 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.040 BindingDB Entry DOI: 10.7270/Q29Z96BF |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50441103
(CHEMBL2430577)Show SMILES CCCOc1c2Cc3cccc(Cc4cccc(Cc5cc(cc(Cc1ccc2)c5O)C(O)(P(O)(O)=O)P(O)(O)=O)c4OCCC)c3O Show InChI InChI=1S/C35H40O11P2/c1-3-14-45-33-24-10-6-12-26(33)18-28-20-30(35(38,47(39,40)41)48(42,43)44)21-29(32(28)37)19-27-13-7-11-25(34(27)46-15-4-2)17-23-9-5-8-22(16-24)31(23)36/h5-13,20-21,36-38H,3-4,14-19H2,1-2H3,(H2,39,40,41)(H2,42,43,44) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Academy of Sciences of Ukraine
Curated by ChEMBL
| Assay Description Inhibition of recombinant full length PTP1B (unknown origin) assessed as p-nitrophenyl phosphate conversion to p-nitrophenol after 10 mins by spectro... |
Bioorg Med Chem Lett 23: 5619-23 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.040 BindingDB Entry DOI: 10.7270/Q29Z96BF |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 11
(Homo sapiens (Human)) | BDBM50441103
(CHEMBL2430577)Show SMILES CCCOc1c2Cc3cccc(Cc4cccc(Cc5cc(cc(Cc1ccc2)c5O)C(O)(P(O)(O)=O)P(O)(O)=O)c4OCCC)c3O Show InChI InChI=1S/C35H40O11P2/c1-3-14-45-33-24-10-6-12-26(33)18-28-20-30(35(38,47(39,40)41)48(42,43)44)21-29(32(28)37)19-27-13-7-11-25(34(27)46-15-4-2)17-23-9-5-8-22(16-24)31(23)36/h5-13,20-21,36-38H,3-4,14-19H2,1-2H3,(H2,39,40,41)(H2,42,43,44) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Academy of Sciences of Ukraine
Curated by ChEMBL
| Assay Description Inhibition of SHP2 (unknown origin) assessed as p-nitrophenyl phosphate conversion to p-nitrophenol after 10 mins by spectrophotometric analysis |
Bioorg Med Chem Lett 23: 5619-23 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.040 BindingDB Entry DOI: 10.7270/Q29Z96BF |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50441103
(CHEMBL2430577)Show SMILES CCCOc1c2Cc3cccc(Cc4cccc(Cc5cc(cc(Cc1ccc2)c5O)C(O)(P(O)(O)=O)P(O)(O)=O)c4OCCC)c3O Show InChI InChI=1S/C35H40O11P2/c1-3-14-45-33-24-10-6-12-26(33)18-28-20-30(35(38,47(39,40)41)48(42,43)44)21-29(32(28)37)19-27-13-7-11-25(34(27)46-15-4-2)17-23-9-5-8-22(16-24)31(23)36/h5-13,20-21,36-38H,3-4,14-19H2,1-2H3,(H2,39,40,41)(H2,42,43,44) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Academy of Sciences of Ukraine
Curated by ChEMBL
| Assay Description Inhibition of recombinant truncated PTP1B (unknown origin) using pTyr1146 as substrate assessed as inorganic phosphate level after 20 mins by spectro... |
Bioorg Med Chem Lett 23: 5619-23 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.040 BindingDB Entry DOI: 10.7270/Q29Z96BF |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase C
(Homo sapiens (Human)) | BDBM50441103
(CHEMBL2430577)Show SMILES CCCOc1c2Cc3cccc(Cc4cccc(Cc5cc(cc(Cc1ccc2)c5O)C(O)(P(O)(O)=O)P(O)(O)=O)c4OCCC)c3O Show InChI InChI=1S/C35H40O11P2/c1-3-14-45-33-24-10-6-12-26(33)18-28-20-30(35(38,47(39,40)41)48(42,43)44)21-29(32(28)37)19-27-13-7-11-25(34(27)46-15-4-2)17-23-9-5-8-22(16-24)31(23)36/h5-13,20-21,36-38H,3-4,14-19H2,1-2H3,(H2,39,40,41)(H2,42,43,44) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Academy of Sciences of Ukraine
Curated by ChEMBL
| Assay Description Inhibition of CD45 (unknown origin) assessed as p-nitrophenyl phosphate conversion to p-nitrophenol after 10 mins by spectrophotometric analysis |
Bioorg Med Chem Lett 23: 5619-23 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.040 BindingDB Entry DOI: 10.7270/Q29Z96BF |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM50441103
(CHEMBL2430577)Show SMILES CCCOc1c2Cc3cccc(Cc4cccc(Cc5cc(cc(Cc1ccc2)c5O)C(O)(P(O)(O)=O)P(O)(O)=O)c4OCCC)c3O Show InChI InChI=1S/C35H40O11P2/c1-3-14-45-33-24-10-6-12-26(33)18-28-20-30(35(38,47(39,40)41)48(42,43)44)21-29(32(28)37)19-27-13-7-11-25(34(27)46-15-4-2)17-23-9-5-8-22(16-24)31(23)36/h5-13,20-21,36-38H,3-4,14-19H2,1-2H3,(H2,39,40,41)(H2,42,43,44) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Academy of Sciences of Ukraine
Curated by ChEMBL
| Assay Description Inhibition of PTPbeta (unknown origin) assessed as p-nitrophenyl phosphate conversion to p-nitrophenol after 10 mins by spectrophotometric analysis |
Bioorg Med Chem Lett 23: 5619-23 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.040 BindingDB Entry DOI: 10.7270/Q29Z96BF |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human)) | BDBM50441103
(CHEMBL2430577)Show SMILES CCCOc1c2Cc3cccc(Cc4cccc(Cc5cc(cc(Cc1ccc2)c5O)C(O)(P(O)(O)=O)P(O)(O)=O)c4OCCC)c3O Show InChI InChI=1S/C35H40O11P2/c1-3-14-45-33-24-10-6-12-26(33)18-28-20-30(35(38,47(39,40)41)48(42,43)44)21-29(32(28)37)19-27-13-7-11-25(34(27)46-15-4-2)17-23-9-5-8-22(16-24)31(23)36/h5-13,20-21,36-38H,3-4,14-19H2,1-2H3,(H2,39,40,41)(H2,42,43,44) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Academy of Sciences of Ukraine
Curated by ChEMBL
| Assay Description Inhibition of TCPTP (unknown origin) assessed as p-nitrophenyl phosphate conversion to p-nitrophenol after 10 mins by spectrophotometric analysis |
Bioorg Med Chem Lett 23: 5619-23 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.040 BindingDB Entry DOI: 10.7270/Q29Z96BF |
More data for this Ligand-Target Pair | |