Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 272.7 BDBM50139826

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50139826 (10-Chloro-6-hydroxy-5-propyl-pyrido[1,2-a]quinolin...) Show SMILES CCCc1c(O)c2cccc(Cl)c2[n+]2ccccc12 Show InChI InChI=1S/C16H14ClNO/c1-2-6-11-14-9-3-4-10-18(14)15-12(16(11)19)7-5-8-13(15)17/h3-5,7-10H,2,6H2,1H3/p+1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.42E+4	n/a	n/a	n/a	n/a
Université de Poitiers Curated by ChEMBL					Assay Description Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM Fsk				J Med Chem 47: 962-72 (2004) Article DOI: 10.1021/jm0308848 BindingDB Entry DOI: 10.7270/Q2NV9HPQ
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50139826 (10-Chloro-6-hydroxy-5-propyl-pyrido[1,2-a]quinolin...) Show SMILES CCCc1c(O)c2cccc(Cl)c2[n+]2ccccc12 Show InChI InChI=1S/C16H14ClNO/c1-2-6-11-14-9-3-4-10-18(14)15-12(16(11)19)7-5-8-13(15)17/h3-5,7-10H,2,6H2,1H3/p+1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.80E+4	n/a	n/a	n/a	n/a
Université de Poitiers Curated by ChEMBL					Assay Description Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM Fsk				J Med Chem 47: 962-72 (2004) Article DOI: 10.1021/jm0308848 BindingDB Entry DOI: 10.7270/Q2NV9HPQ
					More data for this Ligand-Target Pair