Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cysteinyl leukotriene receptor 1
(Homo sapiens (Human)) | BDBM50207399
(CHEMBL3913281)Show SMILES CCCc1c(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O Show InChI InChI=1S/C24H23N5O4/c1-3-4-20-21(10-9-19(15(2)30)23(20)31)32-14-16-5-7-18(8-6-16)33-22-13-17(11-12-25-22)24-26-28-29-27-24/h5-13,31H,3-4,14H2,1-2H3,(H,26,27,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le... |
Bioorg Med Chem Lett 27: 323-328 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.049 BindingDB Entry DOI: 10.7270/Q2DN471R |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50207399
(CHEMBL3913281)Show SMILES CCCc1c(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O Show InChI InChI=1S/C24H23N5O4/c1-3-4-20-21(10-9-19(15(2)30)23(20)31)32-14-16-5-7-18(8-6-16)33-22-13-17(11-12-25-22)24-26-28-29-27-24/h5-13,31H,3-4,14H2,1-2H3,(H,26,27,28,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 470 | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta... |
Bioorg Med Chem Lett 27: 323-328 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.049 BindingDB Entry DOI: 10.7270/Q2DN471R |
More data for this Ligand-Target Pair | |