Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359187
(US10220048, Compound AA97 | US10952992, No. AA97 |...)Show SMILES CCCc1nnc(N[C@@H](Cc2ccc(NS(O)(=O)=O)cc2)c2csc(n2)-c2cccs2)s1 |r| Show InChI InChI=1S/C20H21N5O3S4/c1-2-4-18-23-24-20(31-18)22-15(16-12-30-19(21-16)17-5-3-10-29-17)11-13-6-8-14(9-7-13)25-32(26,27)28/h3,5-10,12,15,25H,2,4,11H2,1H3,(H,22,24)(H,26,27,28)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO THERAPEUTICS, INC.
US Patent
| Assay Description HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N... |
US Patent US10220048 (2019)
BindingDB Entry DOI: 10.7270/Q2VT1VC9 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359187
(US10220048, Compound AA97 | US10952992, No. AA97 |...)Show SMILES CCCc1nnc(N[C@@H](Cc2ccc(NS(O)(=O)=O)cc2)c2csc(n2)-c2cccs2)s1 |r| Show InChI InChI=1S/C20H21N5O3S4/c1-2-4-18-23-24-20(31-18)22-15(16-12-30-19(21-16)17-5-3-10-29-17)11-13-6-8-14(9-7-13)25-32(26,27)28/h3,5-10,12,15,25H,2,4,11H2,1H3,(H,22,24)(H,26,27,28)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RV0SPJ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359187
(US10220048, Compound AA97 | US10952992, No. AA97 |...)Show SMILES CCCc1nnc(N[C@@H](Cc2ccc(NS(O)(=O)=O)cc2)c2csc(n2)-c2cccs2)s1 |r| Show InChI InChI=1S/C20H21N5O3S4/c1-2-4-18-23-24-20(31-18)22-15(16-12-30-19(21-16)17-5-3-10-29-17)11-13-6-8-14(9-7-13)25-32(26,27)28/h3,5-10,12,15,25H,2,4,11H2,1H3,(H,22,24)(H,26,27,28)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Non-limiting examples of the HPTPβ IC50 (μM) activity. |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2668HD5 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359187
(US10220048, Compound AA97 | US10952992, No. AA97 |...)Show SMILES CCCc1nnc(N[C@@H](Cc2ccc(NS(O)(=O)=O)cc2)c2csc(n2)-c2cccs2)s1 |r| Show InChI InChI=1S/C20H21N5O3S4/c1-2-4-18-23-24-20(31-18)22-15(16-12-30-19(21-16)17-5-3-10-29-17)11-13-6-8-14(9-7-13)25-32(26,27)28/h3,5-10,12,15,25H,2,4,11H2,1H3,(H,22,24)(H,26,27,28)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO PHARMACEUTICALS, INC.
US Patent
| Assay Description Non-limiting examples of the HPTP-β IC50 (μM) activity. |
US Patent US10952992 (2021)
BindingDB Entry DOI: 10.7270/Q2FR00R3 |
More data for this Ligand-Target Pair | |