Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50299174
((6aR,9R)-N9,N9-diethyl-N7-m-tolyl-6,6a,8,9-tetrahy...)Show SMILES CCN(CC)C(=O)[C@H]1CN([C@@H]2Cc3c[nH]c4cccc(C2=C1)c34)C(=O)Nc1cccc(C)c1 |r,c:21| Show InChI InChI=1S/C27H30N4O2/c1-4-30(5-2)26(32)19-13-22-21-10-7-11-23-25(21)18(15-28-23)14-24(22)31(16-19)27(33)29-20-9-6-8-17(3)12-20/h6-13,15,19,24,28H,4-5,14,16H2,1-3H3,(H,29,33)/t19-,24-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Antagonist activity at human CXCR3 expressed in L1.2 cells assessed as inhibition of I-TAC-induced Ca2+ mobilization by FLIPR assay |
Bioorg Med Chem Lett 19: 6185-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.002 BindingDB Entry DOI: 10.7270/Q2VX0GJN |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50299174
((6aR,9R)-N9,N9-diethyl-N7-m-tolyl-6,6a,8,9-tetrahy...)Show SMILES CCN(CC)C(=O)[C@H]1CN([C@@H]2Cc3c[nH]c4cccc(C2=C1)c34)C(=O)Nc1cccc(C)c1 |r,c:21| Show InChI InChI=1S/C27H30N4O2/c1-4-30(5-2)26(32)19-13-22-21-10-7-11-23-25(21)18(15-28-23)14-24(22)31(16-19)27(33)29-20-9-6-8-17(3)12-20/h6-13,15,19,24,28H,4-5,14,16H2,1-3H3,(H,29,33)/t19-,24-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 231 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Displacement of [125I]I-TAC from human CXCR3 expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 19: 6185-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.002 BindingDB Entry DOI: 10.7270/Q2VX0GJN |
More data for this Ligand-Target Pair | |