Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50299168
((6aR,9R)-phenyl 9-(diethylcarbamoyl)-6,6a,8,9-tetr...)Show SMILES CCN(CC)C(=O)[C@H]1CN([C@@H]2Cc3c[nH]c4cccc(C2=C1)c34)C(=O)Oc1ccccc1 |r,c:21| Show InChI InChI=1S/C26H27N3O3/c1-3-28(4-2)25(30)18-13-21-20-11-8-12-22-24(20)17(15-27-22)14-23(21)29(16-18)26(31)32-19-9-6-5-7-10-19/h5-13,15,18,23,27H,3-4,14,16H2,1-2H3/t18-,23-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 803 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Displacement of [125I]I-TAC from human CXCR3 expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 19: 6185-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.002 BindingDB Entry DOI: 10.7270/Q2VX0GJN |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50299168
((6aR,9R)-phenyl 9-(diethylcarbamoyl)-6,6a,8,9-tetr...)Show SMILES CCN(CC)C(=O)[C@H]1CN([C@@H]2Cc3c[nH]c4cccc(C2=C1)c34)C(=O)Oc1ccccc1 |r,c:21| Show InChI InChI=1S/C26H27N3O3/c1-3-28(4-2)25(30)18-13-21-20-11-8-12-22-24(20)17(15-27-22)14-23(21)29(16-18)26(31)32-19-9-6-5-7-10-19/h5-13,15,18,23,27H,3-4,14,16H2,1-2H3/t18-,23-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 809 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Antagonist activity at human CXCR3 expressed in L1.2 cells assessed as inhibition of I-TAC-induced Ca2+ mobilization by FLIPR assay |
Bioorg Med Chem Lett 19: 6185-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.002 BindingDB Entry DOI: 10.7270/Q2VX0GJN |
More data for this Ligand-Target Pair | |