Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50437010
(CHEMBL2403024)Show SMILES CCN(CC)C(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2c(C)noc2C)cc1F)c1ccccc1 Show InChI InChI=1S/C29H35FN4O3/c1-5-33(6-2)29(36)27(21-10-8-7-9-11-21)22-14-16-34(17-15-22)25-13-12-23(18-24(25)30)31-28(35)26-19(3)32-37-20(26)4/h7-13,18,22,27H,5-6,14-17H2,1-4H3,(H,31,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development LLC
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis |
Bioorg Med Chem Lett 23: 4141-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50437010
(CHEMBL2403024)Show SMILES CCN(CC)C(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2c(C)noc2C)cc1F)c1ccccc1 Show InChI InChI=1S/C29H35FN4O3/c1-5-33(6-2)29(36)27(21-10-8-7-9-11-21)22-14-16-34(17-15-22)25-13-12-23(18-24(25)30)31-28(35)26-19(3)32-37-20(26)4/h7-13,18,22,27H,5-6,14-17H2,1-4H3,(H,31,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development LLC
Curated by ChEMBL
| Assay Description
Inhibition of MTP (unknown origin)-mediated triglyceride transfer from donor to acceptor vesicles preincubated for 5 mins followed by enzyme addition... |
Bioorg Med Chem Lett 23: 4141-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50437010
(CHEMBL2403024)Show SMILES CCN(CC)C(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2c(C)noc2C)cc1F)c1ccccc1 Show InChI InChI=1S/C29H35FN4O3/c1-5-33(6-2)29(36)27(21-10-8-7-9-11-21)22-14-16-34(17-15-22)25-13-12-23(18-24(25)30)31-28(35)26-19(3)32-37-20(26)4/h7-13,18,22,27H,5-6,14-17H2,1-4H3,(H,31,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at NPY-Y2 receptor in human KAN-TS cell membranes assessed as inhibition of PYY-stimulated [35S]GTPgammaS binding preincubated fo... |
Bioorg Med Chem Lett 23: 4141-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8 |
More data for this
Ligand-Target Pair | |