Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 388.4 BDBM50019317

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA-directed RNA polymerase I subunit RPA1 (Homo sapiens (Human))	BDBM50019317 (CHEMBL3289422) Show SMILES CCN(CC)CCNC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O Show InChI InChI=1S/C23H24N4O2/c1-3-26(4-2)13-11-24-22(28)18-10-7-12-27-21(18)25-20-15-17-9-6-5-8-16(17)14-19(20)23(27)29/h5-10,12,14-15H,3-4,11,13H2,1-2H3,(H,24,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University School of Medicine Curated by ChEMBL					Assay Description Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis				J Med Chem 57: 4950-61 (2014) Article DOI: 10.1021/jm5004842 BindingDB Entry DOI: 10.7270/Q2M0470M
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