Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 323.3 BDBM50102781

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50102781 (2-(4-Diethylamino-2-hydroxy-phenyl)-1H-benzoimidaz...) Show SMILES CCN(CC)c1ccc(-c2nc3ccc(cc3[nH]2)C(N)=N)c(O)c1 Show InChI InChI=1S/C18H21N5O/c1-3-23(4-2)12-6-7-13(16(24)10-12)18-21-14-8-5-11(17(19)20)9-15(14)22-18/h5-10,24H,3-4H2,1-2H3,(H3,19,20)(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description ComInhibition of Human Serine Protease Urokinase Plasminogen Activator (u-PA).				J Med Chem 44: 2753-71 (2001) BindingDB Entry DOI: 10.7270/Q2RX9BC7
					More data for this Ligand-Target Pair
Serine protease 1 (Homo sapiens (Human))	BDBM50102781 (2-(4-Diethylamino-2-hydroxy-phenyl)-1H-benzoimidaz...) Show SMILES CCN(CC)c1ccc(-c2nc3ccc(cc3[nH]2)C(N)=N)c(O)c1 Show InChI InChI=1S/C18H21N5O/c1-3-23(4-2)12-6-7-13(16(24)10-12)18-21-14-8-5-11(17(19)20)9-15(14)22-18/h5-10,24H,3-4H2,1-2H3,(H3,19,20)(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of Human Serine Protease Trypsin.				J Med Chem 44: 2753-71 (2001) BindingDB Entry DOI: 10.7270/Q2RX9BC7
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50102781 (2-(4-Diethylamino-2-hydroxy-phenyl)-1H-benzoimidaz...) Show SMILES CCN(CC)c1ccc(-c2nc3ccc(cc3[nH]2)C(N)=N)c(O)c1 Show InChI InChI=1S/C18H21N5O/c1-3-23(4-2)12-6-7-13(16(24)10-12)18-21-14-8-5-11(17(19)20)9-15(14)22-18/h5-10,24H,3-4H2,1-2H3,(H3,19,20)(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity against human coagulation factor X				J Med Chem 44: 2753-71 (2001) BindingDB Entry DOI: 10.7270/Q2RX9BC7
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50102781 (2-(4-Diethylamino-2-hydroxy-phenyl)-1H-benzoimidaz...) Show SMILES CCN(CC)c1ccc(-c2nc3ccc(cc3[nH]2)C(N)=N)c(O)c1 Show InChI InChI=1S/C18H21N5O/c1-3-23(4-2)12-6-7-13(16(24)10-12)18-21-14-8-5-11(17(19)20)9-15(14)22-18/h5-10,24H,3-4H2,1-2H3,(H3,19,20)(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of Human Serine Protease Plasmin.				J Med Chem 44: 2753-71 (2001) BindingDB Entry DOI: 10.7270/Q2RX9BC7
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50102781 (2-(4-Diethylamino-2-hydroxy-phenyl)-1H-benzoimidaz...) Show SMILES CCN(CC)c1ccc(-c2nc3ccc(cc3[nH]2)C(N)=N)c(O)c1 Show InChI InChI=1S/C18H21N5O/c1-3-23(4-2)12-6-7-13(16(24)10-12)18-21-14-8-5-11(17(19)20)9-15(14)22-18/h5-10,24H,3-4H2,1-2H3,(H3,19,20)(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	9.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of Human Serine Protease Thrombin.				J Med Chem 44: 2753-71 (2001) BindingDB Entry DOI: 10.7270/Q2RX9BC7
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50102781 (2-(4-Diethylamino-2-hydroxy-phenyl)-1H-benzoimidaz...) Show SMILES CCN(CC)c1ccc(-c2nc3ccc(cc3[nH]2)C(N)=N)c(O)c1 Show InChI InChI=1S/C18H21N5O/c1-3-23(4-2)12-6-7-13(16(24)10-12)18-21-14-8-5-11(17(19)20)9-15(14)22-18/h5-10,24H,3-4H2,1-2H3,(H3,19,20)(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of Human Serine Protease tissue type Plasminogen Activator (t-PA).				J Med Chem 44: 2753-71 (2001) BindingDB Entry DOI: 10.7270/Q2RX9BC7
					More data for this Ligand-Target Pair