Found 6 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50421023
(CHEMBL2086749)Show SMILES CCN1CCC(CC1)Oc1ccc2NC(=O)C(=C(c3nc4ccc(OC)cc4[nH]3)c3ccccc3)c2c1 |w:17.18| Show InChI InChI=1S/C30H30N4O3/c1-3-34-15-13-20(14-16-34)37-22-10-11-24-23(17-22)28(30(35)33-24)27(19-7-5-4-6-8-19)29-31-25-12-9-21(36-2)18-26(25)32-29/h4-12,17-18,20H,3,13-16H2,1-2H3,(H,31,32)(H,33,35) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Exelixis
Curated by ChEMBL
| Assay Description Inhibition of N-terminal GST-tagged PDGFRalpha after 2 hrs by luciferase-luciferin coupled chemiluminescence assay |
Bioorg Med Chem Lett 22: 4979-85 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.029 BindingDB Entry DOI: 10.7270/Q2XG9SD4 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50421023
(CHEMBL2086749)Show SMILES CCN1CCC(CC1)Oc1ccc2NC(=O)C(=C(c3nc4ccc(OC)cc4[nH]3)c3ccccc3)c2c1 |w:17.18| Show InChI InChI=1S/C30H30N4O3/c1-3-34-15-13-20(14-16-34)37-22-10-11-24-23(17-22)28(30(35)33-24)27(19-7-5-4-6-8-19)29-31-25-12-9-21(36-2)18-26(25)32-29/h4-12,17-18,20H,3,13-16H2,1-2H3,(H,31,32)(H,33,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Exelixis
Curated by ChEMBL
| Assay Description Inhibition of N-terminal GST-tagged FGFR1 using poly(Glu,Tyr) as substrate after 30 mins by alphascreen assay |
Bioorg Med Chem Lett 22: 4979-85 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.029 BindingDB Entry DOI: 10.7270/Q2XG9SD4 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50421023
(CHEMBL2086749)Show SMILES CCN1CCC(CC1)Oc1ccc2NC(=O)C(=C(c3nc4ccc(OC)cc4[nH]3)c3ccccc3)c2c1 |w:17.18| Show InChI InChI=1S/C30H30N4O3/c1-3-34-15-13-20(14-16-34)37-22-10-11-24-23(17-22)28(30(35)33-24)27(19-7-5-4-6-8-19)29-31-25-12-9-21(36-2)18-26(25)32-29/h4-12,17-18,20H,3,13-16H2,1-2H3,(H,31,32)(H,33,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Exelixis
Curated by ChEMBL
| Assay Description Inhibition of N-terminal GST-tagged KDR after 4 hrs by luciferase-luciferin coupled chemiluminescence assay |
Bioorg Med Chem Lett 22: 4979-85 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.029 BindingDB Entry DOI: 10.7270/Q2XG9SD4 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50421023
(CHEMBL2086749)Show SMILES CCN1CCC(CC1)Oc1ccc2NC(=O)C(=C(c3nc4ccc(OC)cc4[nH]3)c3ccccc3)c2c1 |w:17.18| Show InChI InChI=1S/C30H30N4O3/c1-3-34-15-13-20(14-16-34)37-22-10-11-24-23(17-22)28(30(35)33-24)27(19-7-5-4-6-8-19)29-31-25-12-9-21(36-2)18-26(25)32-29/h4-12,17-18,20H,3,13-16H2,1-2H3,(H,31,32)(H,33,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 213 | n/a | n/a | n/a | n/a | n/a | n/a |
Exelixis
Curated by ChEMBL
| Assay Description Inhibition of KDR in human HUVEC cells assessed as inhibition of VEGF-induced ERK phosphorylation incubated for 1 hr prior to VEGF-stimulation measur... |
Bioorg Med Chem Lett 22: 4979-85 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.029 BindingDB Entry DOI: 10.7270/Q2XG9SD4 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50421023
(CHEMBL2086749)Show SMILES CCN1CCC(CC1)Oc1ccc2NC(=O)C(=C(c3nc4ccc(OC)cc4[nH]3)c3ccccc3)c2c1 |w:17.18| Show InChI InChI=1S/C30H30N4O3/c1-3-34-15-13-20(14-16-34)37-22-10-11-24-23(17-22)28(30(35)33-24)27(19-7-5-4-6-8-19)29-31-25-12-9-21(36-2)18-26(25)32-29/h4-12,17-18,20H,3,13-16H2,1-2H3,(H,31,32)(H,33,35) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 691 | n/a | n/a | n/a | n/a | n/a | n/a |
Exelixis
Curated by ChEMBL
| Assay Description Inhibition of N-terminal GST-tagged Flt1 using poly(Glu,Tyr) as substrate after 60 mins by alphascreen assay |
Bioorg Med Chem Lett 22: 4979-85 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.029 BindingDB Entry DOI: 10.7270/Q2XG9SD4 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50421023
(CHEMBL2086749)Show SMILES CCN1CCC(CC1)Oc1ccc2NC(=O)C(=C(c3nc4ccc(OC)cc4[nH]3)c3ccccc3)c2c1 |w:17.18| Show InChI InChI=1S/C30H30N4O3/c1-3-34-15-13-20(14-16-34)37-22-10-11-24-23(17-22)28(30(35)33-24)27(19-7-5-4-6-8-19)29-31-25-12-9-21(36-2)18-26(25)32-29/h4-12,17-18,20H,3,13-16H2,1-2H3,(H,31,32)(H,33,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 736 | n/a | n/a | n/a | n/a | n/a | n/a |
Exelixis
Curated by ChEMBL
| Assay Description Inhibition of FGFR1 in human SK-N-MC cells assessed as inhibition of FGF-induced ERK phosphorylation incubated for 1 hr prior to VEGF-stimulation mea... |
Bioorg Med Chem Lett 22: 4979-85 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.029 BindingDB Entry DOI: 10.7270/Q2XG9SD4 |
More data for this Ligand-Target Pair | |