Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359182
(US10220048, Compound AA92 | US10952992, No. AA92 |...)Show SMILES CCN1CCN(CC(=O)N[C@@H](Cc2ccc(NS(O)(=O)=O)cc2)c2nc(CC)cs2)C(=O)C1=O |r| Show InChI InChI=1S/C21H27N5O6S2/c1-3-15-13-33-19(22-15)17(11-14-5-7-16(8-6-14)24-34(30,31)32)23-18(27)12-26-10-9-25(4-2)20(28)21(26)29/h5-8,13,17,24H,3-4,9-12H2,1-2H3,(H,23,27)(H,30,31,32)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO THERAPEUTICS, INC.
US Patent
| Assay Description HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N... |
US Patent US10220048 (2019)
BindingDB Entry DOI: 10.7270/Q2VT1VC9 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359182
(US10220048, Compound AA92 | US10952992, No. AA92 |...)Show SMILES CCN1CCN(CC(=O)N[C@@H](Cc2ccc(NS(O)(=O)=O)cc2)c2nc(CC)cs2)C(=O)C1=O |r| Show InChI InChI=1S/C21H27N5O6S2/c1-3-15-13-33-19(22-15)17(11-14-5-7-16(8-6-14)24-34(30,31)32)23-18(27)12-26-10-9-25(4-2)20(28)21(26)29/h5-8,13,17,24H,3-4,9-12H2,1-2H3,(H,23,27)(H,30,31,32)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RV0SPJ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359182
(US10220048, Compound AA92 | US10952992, No. AA92 |...)Show SMILES CCN1CCN(CC(=O)N[C@@H](Cc2ccc(NS(O)(=O)=O)cc2)c2nc(CC)cs2)C(=O)C1=O |r| Show InChI InChI=1S/C21H27N5O6S2/c1-3-15-13-33-19(22-15)17(11-14-5-7-16(8-6-14)24-34(30,31)32)23-18(27)12-26-10-9-25(4-2)20(28)21(26)29/h5-8,13,17,24H,3-4,9-12H2,1-2H3,(H,23,27)(H,30,31,32)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Non-limiting examples of the HPTPβ IC50 (μM) activity. |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2668HD5 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359182
(US10220048, Compound AA92 | US10952992, No. AA92 |...)Show SMILES CCN1CCN(CC(=O)N[C@@H](Cc2ccc(NS(O)(=O)=O)cc2)c2nc(CC)cs2)C(=O)C1=O |r| Show InChI InChI=1S/C21H27N5O6S2/c1-3-15-13-33-19(22-15)17(11-14-5-7-16(8-6-14)24-34(30,31)32)23-18(27)12-26-10-9-25(4-2)20(28)21(26)29/h5-8,13,17,24H,3-4,9-12H2,1-2H3,(H,23,27)(H,30,31,32)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO PHARMACEUTICALS, INC.
US Patent
| Assay Description Non-limiting examples of the HPTP-β IC50 (μM) activity. |
US Patent US10952992 (2021)
BindingDB Entry DOI: 10.7270/Q2FR00R3 |
More data for this Ligand-Target Pair | |