Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50437009
(CHEMBL2403027)Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)Nc2c(C)noc2C)cc1F)c1ccccc1 Show InChI InChI=1S/C27H32FN5O3/c1-4-29-26(34)24(19-8-6-5-7-9-19)20-12-14-33(15-13-20)23-11-10-21(16-22(23)28)30-27(35)31-25-17(2)32-36-18(25)3/h5-11,16,20,24H,4,12-15H2,1-3H3,(H,29,34)(H2,30,31,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development LLC
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis |
Bioorg Med Chem Lett 23: 4141-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50437009
(CHEMBL2403027)Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)Nc2c(C)noc2C)cc1F)c1ccccc1 Show InChI InChI=1S/C27H32FN5O3/c1-4-29-26(34)24(19-8-6-5-7-9-19)20-12-14-33(15-13-20)23-11-10-21(16-22(23)28)30-27(35)31-25-17(2)32-36-18(25)3/h5-11,16,20,24H,4,12-15H2,1-3H3,(H,29,34)(H2,30,31,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development LLC
Curated by ChEMBL
| Assay Description
Inhibition of MTP (unknown origin)-mediated triglyceride transfer from donor to acceptor vesicles preincubated for 5 mins followed by enzyme addition... |
Bioorg Med Chem Lett 23: 4141-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50437009
(CHEMBL2403027)Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)Nc2c(C)noc2C)cc1F)c1ccccc1 Show InChI InChI=1S/C27H32FN5O3/c1-4-29-26(34)24(19-8-6-5-7-9-19)20-12-14-33(15-13-20)23-11-10-21(16-22(23)28)30-27(35)31-25-17(2)32-36-18(25)3/h5-11,16,20,24H,4,12-15H2,1-3H3,(H,29,34)(H2,30,31,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at NPY-Y2 receptor in human KAN-TS cell membranes assessed as inhibition of PYY-stimulated [35S]GTPgammaS binding preincubated fo... |
Bioorg Med Chem Lett 23: 4141-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8 |
More data for this
Ligand-Target Pair | |