Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S]
(Homo sapiens (Human)) | BDBM384502
(US10590114, No. 188 | US11111235, No. 188 | US1159...)Show SMILES CCNc1nc(Nc2ccnn2[C@@H]2C[C@@H](C2)n2nccn2)ncc1C(F)(F)F |r,wU:12.12,14.17,(7.74,-2.67,;6.41,-1.9,;6.41,-.36,;5.08,.41,;3.74,-.36,;2.41,.41,;1.07,-.36,;1.07,-1.9,;2.32,-2.8,;1.84,-4.26,;.3,-4.26,;-.17,-2.8,;-1.66,-2.4,;-2.43,-1.07,;-3.76,-1.84,;-2.99,-3.17,;-5.25,-1.44,;-5.73,.03,;-7.27,.03,;-7.74,-1.44,;-6.5,-2.34,;2.41,1.95,;3.74,2.72,;5.08,1.95,;6.41,2.72,;6.41,4.26,;7.74,1.95,;7.74,3.49,)| Show InChI InChI=1S/C16H18F3N9/c1-2-20-14-12(16(17,18)19)9-21-15(26-14)25-13-3-4-22-27(13)10-7-11(8-10)28-23-5-6-24-28/h3-6,9-11H,2,7-8H2,1H3,(H2,20,21,25,26)/t10-,11+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
| Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well... |
Bioorg Med Chem Lett 18: 2567-73 (2008)
BindingDB Entry DOI: 10.7270/Q29G5Q4M |
More data for this
Ligand-Target Pair | |
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S]
(Homo sapiens (Human)) | BDBM384502
(US10590114, No. 188 | US11111235, No. 188 | US1159...)Show SMILES CCNc1nc(Nc2ccnn2[C@@H]2C[C@@H](C2)n2nccn2)ncc1C(F)(F)F |r,wU:12.12,14.17,(7.74,-2.67,;6.41,-1.9,;6.41,-.36,;5.08,.41,;3.74,-.36,;2.41,.41,;1.07,-.36,;1.07,-1.9,;2.32,-2.8,;1.84,-4.26,;.3,-4.26,;-.17,-2.8,;-1.66,-2.4,;-2.43,-1.07,;-3.76,-1.84,;-2.99,-3.17,;-5.25,-1.44,;-5.73,.03,;-7.27,.03,;-7.74,-1.44,;-6.5,-2.34,;2.41,1.95,;3.74,2.72,;5.08,1.95,;6.41,2.72,;6.41,4.26,;7.74,1.95,;7.74,3.49,)| Show InChI InChI=1S/C16H18F3N9/c1-2-20-14-12(16(17,18)19)9-21-15(26-14)25-13-3-4-22-27(13)10-7-11(8-10)28-23-5-6-24-28/h3-6,9-11H,2,7-8H2,1H3,(H2,20,21,25,26)/t10-,11+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Compounds were prepared by initially diluting to 1 mM with DMSO. 35 μL of reference compound solution, 35 μL of test compound solution, and... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2SJ1QJH |
More data for this
Ligand-Target Pair | |
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S]
(Homo sapiens (Human)) | BDBM384502
(US10590114, No. 188 | US11111235, No. 188 | US1159...)Show SMILES CCNc1nc(Nc2ccnn2[C@@H]2C[C@@H](C2)n2nccn2)ncc1C(F)(F)F |r,wU:12.12,14.17,(7.74,-2.67,;6.41,-1.9,;6.41,-.36,;5.08,.41,;3.74,-.36,;2.41,.41,;1.07,-.36,;1.07,-1.9,;2.32,-2.8,;1.84,-4.26,;.3,-4.26,;-.17,-2.8,;-1.66,-2.4,;-2.43,-1.07,;-3.76,-1.84,;-2.99,-3.17,;-5.25,-1.44,;-5.73,.03,;-7.27,.03,;-7.74,-1.44,;-6.5,-2.34,;2.41,1.95,;3.74,2.72,;5.08,1.95,;6.41,2.72,;6.41,4.26,;7.74,1.95,;7.74,3.49,)| Show InChI InChI=1S/C16H18F3N9/c1-2-20-14-12(16(17,18)19)9-21-15(26-14)25-13-3-4-22-27(13)10-7-11(8-10)28-23-5-6-24-28/h3-6,9-11H,2,7-8H2,1H3,(H2,20,21,25,26)/t10-,11+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme Reaction Conditions50 mM ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2P84G2S |
More data for this
Ligand-Target Pair | |
Leucine-rich repeat serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM384502
(US10590114, No. 188 | US11111235, No. 188 | US1159...)Show SMILES CCNc1nc(Nc2ccnn2[C@@H]2C[C@@H](C2)n2nccn2)ncc1C(F)(F)F |r,wU:12.12,14.17,(7.74,-2.67,;6.41,-1.9,;6.41,-.36,;5.08,.41,;3.74,-.36,;2.41,.41,;1.07,-.36,;1.07,-1.9,;2.32,-2.8,;1.84,-4.26,;.3,-4.26,;-.17,-2.8,;-1.66,-2.4,;-2.43,-1.07,;-3.76,-1.84,;-2.99,-3.17,;-5.25,-1.44,;-5.73,.03,;-7.27,.03,;-7.74,-1.44,;-6.5,-2.34,;2.41,1.95,;3.74,2.72,;5.08,1.95,;6.41,2.72,;6.41,4.26,;7.74,1.95,;7.74,3.49,)| Show InChI InChI=1S/C16H18F3N9/c1-2-20-14-12(16(17,18)19)9-21-15(26-14)25-13-3-4-22-27(13)10-7-11(8-10)28-23-5-6-24-28/h3-6,9-11H,2,7-8H2,1H3,(H2,20,21,25,26)/t10-,11+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Denali Therapautics Inc.
US Patent
| Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well... |
US Patent US10590114 (2020)
BindingDB Entry DOI: 10.7270/Q2DJ5JNW |
More data for this
Ligand-Target Pair | |