Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S]
(Homo sapiens (Human)) | BDBM384350
(US10590114, No. 35B | US11111235, No. 35B | US1159...)Show SMILES CCNc1nc(Nc2cn(nc2C)[C@@H]2C[C@@H](C2)C#N)ncc1C(F)(F)F |r,wD:13.13,15.18,(4.7,.38,;3.37,1.15,;3.37,2.69,;2.03,3.46,;.7,2.69,;-.63,3.46,;-1.97,2.69,;-1.97,1.15,;-.72,.25,;-1.2,-1.22,;-2.74,-1.22,;-3.21,.25,;-4.7,.65,;-.43,-2.55,;1.06,-2.95,;.67,-4.46,;-.83,-4.04,;1.44,-5.79,;2.21,-7.13,;-.63,5,;.7,5.77,;2.08,5.03,;3.42,5.8,;4.75,6.57,;2.65,7.13,;4.19,4.47,)| Show InChI InChI=1S/C16H18F3N7/c1-3-21-14-12(16(17,18)19)7-22-15(24-14)23-13-8-26(25-9(13)2)11-4-10(5-11)6-20/h7-8,10-11H,3-5H2,1-2H3,(H2,21,22,23,24)/t10-,11+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <30 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
| Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well... |
Bioorg Med Chem Lett 18: 2567-73 (2008)
BindingDB Entry DOI: 10.7270/Q29G5Q4M |
More data for this
Ligand-Target Pair | |
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S]
(Homo sapiens (Human)) | BDBM384350
(US10590114, No. 35B | US11111235, No. 35B | US1159...)Show SMILES CCNc1nc(Nc2cn(nc2C)[C@@H]2C[C@@H](C2)C#N)ncc1C(F)(F)F |r,wD:13.13,15.18,(4.7,.38,;3.37,1.15,;3.37,2.69,;2.03,3.46,;.7,2.69,;-.63,3.46,;-1.97,2.69,;-1.97,1.15,;-.72,.25,;-1.2,-1.22,;-2.74,-1.22,;-3.21,.25,;-4.7,.65,;-.43,-2.55,;1.06,-2.95,;.67,-4.46,;-.83,-4.04,;1.44,-5.79,;2.21,-7.13,;-.63,5,;.7,5.77,;2.08,5.03,;3.42,5.8,;4.75,6.57,;2.65,7.13,;4.19,4.47,)| Show InChI InChI=1S/C16H18F3N7/c1-3-21-14-12(16(17,18)19)7-22-15(24-14)23-13-8-26(25-9(13)2)11-4-10(5-11)6-20/h7-8,10-11H,3-5H2,1-2H3,(H2,21,22,23,24)/t10-,11+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Compounds were prepared by initially diluting to 1 mM with DMSO. 35 μL of reference compound solution, 35 μL of test compound solution, and... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2SJ1QJH |
More data for this
Ligand-Target Pair | |
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S]
(Homo sapiens (Human)) | BDBM384350
(US10590114, No. 35B | US11111235, No. 35B | US1159...)Show SMILES CCNc1nc(Nc2cn(nc2C)[C@@H]2C[C@@H](C2)C#N)ncc1C(F)(F)F |r,wD:13.13,15.18,(4.7,.38,;3.37,1.15,;3.37,2.69,;2.03,3.46,;.7,2.69,;-.63,3.46,;-1.97,2.69,;-1.97,1.15,;-.72,.25,;-1.2,-1.22,;-2.74,-1.22,;-3.21,.25,;-4.7,.65,;-.43,-2.55,;1.06,-2.95,;.67,-4.46,;-.83,-4.04,;1.44,-5.79,;2.21,-7.13,;-.63,5,;.7,5.77,;2.08,5.03,;3.42,5.8,;4.75,6.57,;2.65,7.13,;4.19,4.47,)| Show InChI InChI=1S/C16H18F3N7/c1-3-21-14-12(16(17,18)19)7-22-15(24-14)23-13-8-26(25-9(13)2)11-4-10(5-11)6-20/h7-8,10-11H,3-5H2,1-2H3,(H2,21,22,23,24)/t10-,11+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme Reaction Conditions50 mM ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2P84G2S |
More data for this
Ligand-Target Pair | |
Leucine-rich repeat serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM384350
(US10590114, No. 35B | US11111235, No. 35B | US1159...)Show SMILES CCNc1nc(Nc2cn(nc2C)[C@@H]2C[C@@H](C2)C#N)ncc1C(F)(F)F |r,wD:13.13,15.18,(4.7,.38,;3.37,1.15,;3.37,2.69,;2.03,3.46,;.7,2.69,;-.63,3.46,;-1.97,2.69,;-1.97,1.15,;-.72,.25,;-1.2,-1.22,;-2.74,-1.22,;-3.21,.25,;-4.7,.65,;-.43,-2.55,;1.06,-2.95,;.67,-4.46,;-.83,-4.04,;1.44,-5.79,;2.21,-7.13,;-.63,5,;.7,5.77,;2.08,5.03,;3.42,5.8,;4.75,6.57,;2.65,7.13,;4.19,4.47,)| Show InChI InChI=1S/C16H18F3N7/c1-3-21-14-12(16(17,18)19)7-22-15(24-14)23-13-8-26(25-9(13)2)11-4-10(5-11)6-20/h7-8,10-11H,3-5H2,1-2H3,(H2,21,22,23,24)/t10-,11+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <30 | n/a | n/a | n/a | n/a | n/a | n/a |
Denali Therapautics Inc.
US Patent
| Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well... |
US Patent US10590114 (2020)
BindingDB Entry DOI: 10.7270/Q2DJ5JNW |
More data for this
Ligand-Target Pair | |