Found 10 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50529975
(CHEMBL4539998)Show InChI InChI=1S/C16H18N2O2/c1-3-20-16(19)18-11-10-14(12-18)7-5-9-15-8-4-6-13(2)17-15/h4,6-8H,3,10-12H2,1-2H3/b14-7- | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 243 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysis |
J Med Chem 62: 1246-1273 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01226 BindingDB Entry DOI: 10.7270/Q24171JF |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50529975
(CHEMBL4539998)Show InChI InChI=1S/C16H18N2O2/c1-3-20-16(19)18-11-10-14(12-18)7-5-9-15-8-4-6-13(2)17-15/h4,6-8H,3,10-12H2,1-2H3/b14-7- | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 243 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysis |
J Med Chem 62: 1246-1273 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01226 BindingDB Entry DOI: 10.7270/Q24171JF |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50529975
(CHEMBL4539998)Show InChI InChI=1S/C16H18N2O2/c1-3-20-16(19)18-11-10-14(12-18)7-5-9-15-8-4-6-13(2)17-15/h4,6-8H,3,10-12H2,1-2H3/b14-7- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description Displacement of [3H]MPEP from rat mGlu1 receptor expressed in CHO-TREx cell membranes after 30 mins by liquid scintillation spectrometric analysis |
J Med Chem 62: 1246-1273 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01226 BindingDB Entry DOI: 10.7270/Q24171JF |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50529975
(CHEMBL4539998)Show InChI InChI=1S/C16H18N2O2/c1-3-20-16(19)18-11-10-14(12-18)7-5-9-15-8-4-6-13(2)17-15/h4,6-8H,3,10-12H2,1-2H3/b14-7- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description Displacement of [3H]MPEP from rat mGlu1 receptor expressed in CHO-TREx cell membranes after 30 mins by liquid scintillation spectrometric analysis |
J Med Chem 62: 1246-1273 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01226 BindingDB Entry DOI: 10.7270/Q24171JF |
More data for this Ligand-Target Pair | |
Cytochrome P450 1A2
(Homo sapiens (Human)) | BDBM50529975
(CHEMBL4539998)Show InChI InChI=1S/C16H18N2O2/c1-3-20-16(19)18-11-10-14(12-18)7-5-9-15-8-4-6-13(2)17-15/h4,6-8H,3,10-12H2,1-2H3/b14-7- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <700 | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human CYP1A2 using 3-cyano-7-ethoxycoumarin as substrate preincubated for 10 mins followed by substrate addition and measur... |
J Med Chem 62: 1246-1273 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01226 BindingDB Entry DOI: 10.7270/Q24171JF |
More data for this Ligand-Target Pair | |
Cytochrome P450 1A2
(Homo sapiens (Human)) | BDBM50529975
(CHEMBL4539998)Show InChI InChI=1S/C16H18N2O2/c1-3-20-16(19)18-11-10-14(12-18)7-5-9-15-8-4-6-13(2)17-15/h4,6-8H,3,10-12H2,1-2H3/b14-7- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <700 | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human CYP1A2 using 3-cyano-7-ethoxycoumarin as substrate preincubated for 10 mins followed by substrate addition and measur... |
J Med Chem 62: 1246-1273 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01226 BindingDB Entry DOI: 10.7270/Q24171JF |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50529975
(CHEMBL4539998)Show InChI InChI=1S/C16H18N2O2/c1-3-20-16(19)18-11-10-14(12-18)7-5-9-15-8-4-6-13(2)17-15/h4,6-8H,3,10-12H2,1-2H3/b14-7- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human CYP3A4 using 7-benzyloxy-trifluoromethylcoumarin as substrate preincubated for 10 mins followed by substrate addition... |
J Med Chem 62: 1246-1273 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01226 BindingDB Entry DOI: 10.7270/Q24171JF |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50529975
(CHEMBL4539998)Show InChI InChI=1S/C16H18N2O2/c1-3-20-16(19)18-11-10-14(12-18)7-5-9-15-8-4-6-13(2)17-15/h4,6-8H,3,10-12H2,1-2H3/b14-7- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human CYP3A4 using 7-benzyloxy-trifluoromethylcoumarin as substrate preincubated for 10 mins followed by substrate addition... |
J Med Chem 62: 1246-1273 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01226 BindingDB Entry DOI: 10.7270/Q24171JF |
More data for this Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50529975
(CHEMBL4539998)Show InChI InChI=1S/C16H18N2O2/c1-3-20-16(19)18-11-10-14(12-18)7-5-9-15-8-4-6-13(2)17-15/h4,6-8H,3,10-12H2,1-2H3/b14-7- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human CYP2D6 using 3-[2-(N,N-diethylamino)ethyl]-7-methoxy-4-methylcoumarin as substrate preincubated for 10 mins followed ... |
J Med Chem 62: 1246-1273 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01226 BindingDB Entry DOI: 10.7270/Q24171JF |
More data for this Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50529975
(CHEMBL4539998)Show InChI InChI=1S/C16H18N2O2/c1-3-20-16(19)18-11-10-14(12-18)7-5-9-15-8-4-6-13(2)17-15/h4,6-8H,3,10-12H2,1-2H3/b14-7- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human CYP2D6 using 3-[2-(N,N-diethylamino)ethyl]-7-methoxy-4-methylcoumarin as substrate preincubated for 10 mins followed ... |
J Med Chem 62: 1246-1273 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01226 BindingDB Entry DOI: 10.7270/Q24171JF |
More data for this Ligand-Target Pair | |