Found 6 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 6
(Homo sapiens (Human)) | BDBM444615
(US10662186, Compound 196 | US10988476, Compound I-...)Show SMILES CCOP(=O)(OCC)C1(O)CCN(CCN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 |w:8.7| Show InChI InChI=1S/C34H45F2N8O4P/c1-7-47-49(46,48-8-2)34(45)12-14-43(21-34)16-15-42-13-11-27-23(20-42)9-10-29(39-27)40-32-37-19-26(36)30(41-32)24-17-25(35)31-28(18-24)44(22(3)38-31)33(4,5)6/h9-10,17-19,45H,7-8,11-16,20-21H2,1-6H3,(H,37,39,40,41) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.99 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10988476 (2021)
BindingDB Entry DOI: 10.7270/Q2PR8047 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6
(Homo sapiens (Human)) | BDBM444615
(US10662186, Compound 196 | US10988476, Compound I-...)Show SMILES CCOP(=O)(OCC)C1(O)CCN(CCN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 |w:8.7| Show InChI InChI=1S/C34H45F2N8O4P/c1-7-47-49(46,48-8-2)34(45)12-14-43(21-34)16-15-42-13-11-27-23(20-42)9-10-29(39-27)40-32-37-19-26(36)30(41-32)24-17-25(35)31-28(18-24)44(22(3)38-31)33(4,5)6/h9-10,17-19,45H,7-8,11-16,20-21H2,1-6H3,(H,37,39,40,41) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.99 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10662186 (2020)
BindingDB Entry DOI: 10.7270/Q2GX4FKS |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM444615
(US10662186, Compound 196 | US10988476, Compound I-...)Show SMILES CCOP(=O)(OCC)C1(O)CCN(CCN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 |w:8.7| Show InChI InChI=1S/C34H45F2N8O4P/c1-7-47-49(46,48-8-2)34(45)12-14-43(21-34)16-15-42-13-11-27-23(20-42)9-10-29(39-27)40-32-37-19-26(36)30(41-32)24-17-25(35)31-28(18-24)44(22(3)38-31)33(4,5)6/h9-10,17-19,45H,7-8,11-16,20-21H2,1-6H3,(H,37,39,40,41) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.06 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10662186 (2020)
BindingDB Entry DOI: 10.7270/Q2GX4FKS |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM444615
(US10662186, Compound 196 | US10988476, Compound I-...)Show SMILES CCOP(=O)(OCC)C1(O)CCN(CCN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 |w:8.7| Show InChI InChI=1S/C34H45F2N8O4P/c1-7-47-49(46,48-8-2)34(45)12-14-43(21-34)16-15-42-13-11-27-23(20-42)9-10-29(39-27)40-32-37-19-26(36)30(41-32)24-17-25(35)31-28(18-24)44(22(3)38-31)33(4,5)6/h9-10,17-19,45H,7-8,11-16,20-21H2,1-6H3,(H,37,39,40,41) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.06 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10988476 (2021)
BindingDB Entry DOI: 10.7270/Q2PR8047 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM444615
(US10662186, Compound 196 | US10988476, Compound I-...)Show SMILES CCOP(=O)(OCC)C1(O)CCN(CCN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 |w:8.7| Show InChI InChI=1S/C34H45F2N8O4P/c1-7-47-49(46,48-8-2)34(45)12-14-43(21-34)16-15-42-13-11-27-23(20-42)9-10-29(39-27)40-32-37-19-26(36)30(41-32)24-17-25(35)31-28(18-24)44(22(3)38-31)33(4,5)6/h9-10,17-19,45H,7-8,11-16,20-21H2,1-6H3,(H,37,39,40,41) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 60.2 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10988476 (2021)
BindingDB Entry DOI: 10.7270/Q2PR8047 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM444615
(US10662186, Compound 196 | US10988476, Compound I-...)Show SMILES CCOP(=O)(OCC)C1(O)CCN(CCN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 |w:8.7| Show InChI InChI=1S/C34H45F2N8O4P/c1-7-47-49(46,48-8-2)34(45)12-14-43(21-34)16-15-42-13-11-27-23(20-42)9-10-29(39-27)40-32-37-19-26(36)30(41-32)24-17-25(35)31-28(18-24)44(22(3)38-31)33(4,5)6/h9-10,17-19,45H,7-8,11-16,20-21H2,1-6H3,(H,37,39,40,41) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 60.2 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10662186 (2020)
BindingDB Entry DOI: 10.7270/Q2GX4FKS |
More data for this
Ligand-Target Pair | |