Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50310480
(CHEMBL1077825 | N-((R)-1-(3-(4-ethoxyphenyl)-4-oxo...)Show SMILES CCOc1ccc(cc1)-n1c(nc2ncccc2c1=O)[C@@H](C)N(C[C@@H]1CCCN1C(C)C)C(=O)Cc1ccc(F)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C34H37F4N5O3/c1-5-46-26-13-11-24(12-14-26)43-32(40-31-27(33(43)45)9-6-16-39-31)22(4)42(20-25-8-7-17-41(25)21(2)3)30(44)19-23-10-15-29(35)28(18-23)34(36,37)38/h6,9-16,18,21-22,25H,5,7-8,17,19-20H2,1-4H3/t22-,25+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]-1P10 from human CXCR3 expressed in PBMC after 2 hrs in RPMI buffer by scintillation counting |
Bioorg Med Chem Lett 19: 5114-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.032 BindingDB Entry DOI: 10.7270/Q2FX79KZ |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50310480
(CHEMBL1077825 | N-((R)-1-(3-(4-ethoxyphenyl)-4-oxo...)Show SMILES CCOc1ccc(cc1)-n1c(nc2ncccc2c1=O)[C@@H](C)N(C[C@@H]1CCCN1C(C)C)C(=O)Cc1ccc(F)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C34H37F4N5O3/c1-5-46-26-13-11-24(12-14-26)43-32(40-31-27(33(43)45)9-6-16-39-31)22(4)42(20-25-8-7-17-41(25)21(2)3)30(44)19-23-10-15-29(35)28(18-23)34(36,37)38/h6,9-16,18,21-22,25H,5,7-8,17,19-20H2,1-4H3/t22-,25+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Antagonist activity against human CXCR3 expressed in human PBMC assessed as inhibition of cell migration in response to ITAC in plasma |
Bioorg Med Chem Lett 19: 5114-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.032 BindingDB Entry DOI: 10.7270/Q2FX79KZ |
More data for this Ligand-Target Pair | |