Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50314740
(CHEMBL1089507 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1cccnc1 Show InChI InChI=1S/C21H20F3N5O3/c1-2-32-16-7-5-14(6-8-16)19(30)26-10-11-27-20(31)17-13-29(15-4-3-9-25-12-15)28-18(17)21(22,23)24/h3-9,12-13H,2,10-11H2,1H3,(H,26,30)(H,27,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis |
Bioorg Med Chem 18: 2785-95 (2010)
Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50314740
(CHEMBL1089507 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1cccnc1 Show InChI InChI=1S/C21H20F3N5O3/c1-2-32-16-7-5-14(6-8-16)19(30)26-10-11-27-20(31)17-13-29(15-4-3-9-25-12-15)28-18(17)21(22,23)24/h3-9,12-13H,2,10-11H2,1H3,(H,26,30)(H,27,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal... |
Bioorg Med Chem 18: 2785-95 (2010)
Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8 |
More data for this
Ligand-Target Pair | |