Found 9 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM50148722
(CHEMBL3770980 | US9518026, Example 59 | US9956214,...)Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(CC(C)(C)CO)c(N)c1C(N)=O Show InChI InChI=1S/C20H25N5O3/c1-4-28-15-8-6-12-9-13(5-7-14(12)23-15)17-16(19(22)27)18(21)25(24-17)10-20(2,3)11-26/h5-9,26H,4,10-11,21H2,1-3H3,(H2,22,27) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Uncharacterized protein
(Cryptosporidium parvum) | BDBM50148722
(CHEMBL3770980 | US9518026, Example 59 | US9956214,...)Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(CC(C)(C)CO)c(N)c1C(N)=O Show InChI InChI=1S/C20H25N5O3/c1-4-28-15-8-6-12-9-13(5-7-14(12)23-15)17-16(19(22)27)18(21)25(24-17)10-20(2,3)11-26/h5-9,26H,4,10-11,21H2,1-3H3,(H2,22,27) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50148722
(CHEMBL3770980 | US9518026, Example 59 | US9956214,...)Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(CC(C)(C)CO)c(N)c1C(N)=O Show InChI InChI=1S/C20H25N5O3/c1-4-28-15-8-6-12-9-13(5-7-14(12)23-15)17-16(19(22)27)18(21)25(24-17)10-20(2,3)11-26/h5-9,26H,4,10-11,21H2,1-3H3,(H2,22,27) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description Inhibition of recombinant Toxoplasma gondii CDPK1 using Syntide 2 as substrate assessed as decrease in depletion of ATP after 90 mins by Kinase glo l... |
Bioorg Med Chem Lett 26: 5487-5491 (2016)
Article DOI: 10.1016/j.bmcl.2016.10.014 BindingDB Entry DOI: 10.7270/Q2J968BR |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50148722
(CHEMBL3770980 | US9518026, Example 59 | US9956214,...)Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(CC(C)(C)CO)c(N)c1C(N)=O Show InChI InChI=1S/C20H25N5O3/c1-4-28-15-8-6-12-9-13(5-7-14(12)23-15)17-16(19(22)27)18(21)25(24-17)10-20(2,3)11-26/h5-9,26H,4,10-11,21H2,1-3H3,(H2,22,27) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii CDPK1 assessed as ATP consumption using (Biotin-C6-PLARTLSVAGLPGKK) as substrate after 90 mins by luciferase reporter... |
ACS Med Chem Lett 6: 1184-1189 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00319 BindingDB Entry DOI: 10.7270/Q2NK3GXD |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50148722
(CHEMBL3770980 | US9518026, Example 59 | US9956214,...)Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(CC(C)(C)CO)c(N)c1C(N)=O Show InChI InChI=1S/C20H25N5O3/c1-4-28-15-8-6-12-9-13(5-7-14(12)23-15)17-16(19(22)27)18(21)25(24-17)10-20(2,3)11-26/h5-9,26H,4,10-11,21H2,1-3H3,(H2,22,27) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50148722
(CHEMBL3770980 | US9518026, Example 59 | US9956214,...)Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(CC(C)(C)CO)c(N)c1C(N)=O Show InChI InChI=1S/C20H25N5O3/c1-4-28-15-8-6-12-9-13(5-7-14(12)23-15)17-16(19(22)27)18(21)25(24-17)10-20(2,3)11-26/h5-9,26H,4,10-11,21H2,1-3H3,(H2,22,27) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50148722
(CHEMBL3770980 | US9518026, Example 59 | US9956214,...)Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(CC(C)(C)CO)c(N)c1C(N)=O Show InChI InChI=1S/C20H25N5O3/c1-4-28-15-8-6-12-9-13(5-7-14(12)23-15)17-16(19(22)27)18(21)25(24-17)10-20(2,3)11-26/h5-9,26H,4,10-11,21H2,1-3H3,(H2,22,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description Inhibition of human SRC using Ac-EIYGEFKKK as substrate after 90 mins by luciferase reporter assay |
ACS Med Chem Lett 6: 1184-1189 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00319 BindingDB Entry DOI: 10.7270/Q2NK3GXD |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50148722
(CHEMBL3770980 | US9518026, Example 59 | US9956214,...)Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(CC(C)(C)CO)c(N)c1C(N)=O Show InChI InChI=1S/C20H25N5O3/c1-4-28-15-8-6-12-9-13(5-7-14(12)23-15)17-16(19(22)27)18(21)25(24-17)10-20(2,3)11-26/h5-9,26H,4,10-11,21H2,1-3H3,(H2,22,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description Inhibition of human SRC using Ac-EIYGEFKKK as substrate after 90 mins by Kinase glo luciferase assay |
Bioorg Med Chem Lett 26: 5487-5491 (2016)
Article DOI: 10.1016/j.bmcl.2016.10.014 BindingDB Entry DOI: 10.7270/Q2J968BR |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50148722
(CHEMBL3770980 | US9518026, Example 59 | US9956214,...)Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(CC(C)(C)CO)c(N)c1C(N)=O Show InChI InChI=1S/C20H25N5O3/c1-4-28-15-8-6-12-9-13(5-7-14(12)23-15)17-16(19(22)27)18(21)25(24-17)10-20(2,3)11-26/h5-9,26H,4,10-11,21H2,1-3H3,(H2,22,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of SRC (unknown origin) |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.9b00069 BindingDB Entry DOI: 10.7270/Q2GT5RSJ |
More data for this Ligand-Target Pair | |