Found 5 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM50200558
(CHEMBL3916476 | US9518026, Example 96 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(C)C2CC2)c(N)c1C(N)=O Show InChI InChI=1S/C20H23N5O2/c1-3-27-15-7-6-13-8-14(10-23-16(13)9-15)18-17(20(22)26)19(21)25(24-18)11(2)12-4-5-12/h6-12H,3-5,21H2,1-2H3,(H2,22,26) | UniProtKB/TrEMBL
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50200558
(CHEMBL3916476 | US9518026, Example 96 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(C)C2CC2)c(N)c1C(N)=O Show InChI InChI=1S/C20H23N5O2/c1-3-27-15-7-6-13-8-14(10-23-16(13)9-15)18-17(20(22)26)19(21)25(24-18)11(2)12-4-5-12/h6-12H,3-5,21H2,1-2H3,(H2,22,26) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50200558
(CHEMBL3916476 | US9518026, Example 96 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(C)C2CC2)c(N)c1C(N)=O Show InChI InChI=1S/C20H23N5O2/c1-3-27-15-7-6-13-8-14(10-23-16(13)9-15)18-17(20(22)26)19(21)25(24-18)11(2)12-4-5-12/h6-12H,3-5,21H2,1-2H3,(H2,22,26) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Toxoplasma gondii CDPK1 using Syntide 2 as substrate assessed as decrease in depletion of ATP after 90 mins by Kinase glo l... |
Bioorg Med Chem Lett 26: 5487-5491 (2016)
Article DOI: 10.1016/j.bmcl.2016.10.014
BindingDB Entry DOI: 10.7270/Q2J968BR |
More data for this
Ligand-Target Pair | |
Uncharacterized protein
(Cryptosporidium parvum) | BDBM50200558
(CHEMBL3916476 | US9518026, Example 96 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(C)C2CC2)c(N)c1C(N)=O Show InChI InChI=1S/C20H23N5O2/c1-3-27-15-7-6-13-8-14(10-23-16(13)9-15)18-17(20(22)26)19(21)25(24-18)11(2)12-4-5-12/h6-12H,3-5,21H2,1-2H3,(H2,22,26) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| US Patent
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50200558
(CHEMBL3916476 | US9518026, Example 96 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(C)C2CC2)c(N)c1C(N)=O Show InChI InChI=1S/C20H23N5O2/c1-3-27-15-7-6-13-8-14(10-23-16(13)9-15)18-17(20(22)26)19(21)25(24-18)11(2)12-4-5-12/h6-12H,3-5,21H2,1-2H3,(H2,22,26) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| US Patent
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this
Ligand-Target Pair | |