Found 7 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM50148647
(CHEMBL3769570 | US9518026, Example 53 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(C)CCO)c(N)c1C(N)=O Show InChI InChI=1S/C19H23N5O3/c1-3-27-14-5-4-12-8-13(10-22-15(12)9-14)17-16(19(21)26)18(20)24(23-17)11(2)6-7-25/h4-5,8-11,25H,3,6-7,20H2,1-2H3,(H2,21,26) | UniProtKB/TrEMBL
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50148647
(CHEMBL3769570 | US9518026, Example 53 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(C)CCO)c(N)c1C(N)=O Show InChI InChI=1S/C19H23N5O3/c1-3-27-14-5-4-12-8-13(10-22-15(12)9-14)17-16(19(21)26)18(20)24(23-17)11(2)6-7-25/h4-5,8-11,25H,3,6-7,20H2,1-2H3,(H2,21,26) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| US Patent
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50148647
(CHEMBL3769570 | US9518026, Example 53 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(C)CCO)c(N)c1C(N)=O Show InChI InChI=1S/C19H23N5O3/c1-3-27-14-5-4-12-8-13(10-22-15(12)9-14)17-16(19(21)26)18(20)24(23-17)11(2)6-7-25/h4-5,8-11,25H,3,6-7,20H2,1-2H3,(H2,21,26) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description
Inhibition of Toxoplasma gondii CDPK1 assessed as ATP consumption using (Biotin-C6-PLARTLSVAGLPGKK) as substrate after 90 mins by luciferase reporter... |
ACS Med Chem Lett 6: 1184-1189 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00319
BindingDB Entry DOI: 10.7270/Q2NK3GXD |
More data for this
Ligand-Target Pair | |
Uncharacterized protein
(Cryptosporidium parvum) | BDBM50148647
(CHEMBL3769570 | US9518026, Example 53 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(C)CCO)c(N)c1C(N)=O Show InChI InChI=1S/C19H23N5O3/c1-3-27-14-5-4-12-8-13(10-22-15(12)9-14)17-16(19(21)26)18(20)24(23-17)11(2)6-7-25/h4-5,8-11,25H,3,6-7,20H2,1-2H3,(H2,21,26) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| US Patent
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50148647
(CHEMBL3769570 | US9518026, Example 53 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(C)CCO)c(N)c1C(N)=O Show InChI InChI=1S/C19H23N5O3/c1-3-27-14-5-4-12-8-13(10-22-15(12)9-14)17-16(19(21)26)18(20)24(23-17)11(2)6-7-25/h4-5,8-11,25H,3,6-7,20H2,1-2H3,(H2,21,26) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| US Patent
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50148647
(CHEMBL3769570 | US9518026, Example 53 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(C)CCO)c(N)c1C(N)=O Show InChI InChI=1S/C19H23N5O3/c1-3-27-14-5-4-12-8-13(10-22-15(12)9-14)17-16(19(21)26)18(20)24(23-17)11(2)6-7-25/h4-5,8-11,25H,3,6-7,20H2,1-2H3,(H2,21,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of SRC (unknown origin) |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.9b00069
BindingDB Entry DOI: 10.7270/Q2GT5RSJ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50148647
(CHEMBL3769570 | US9518026, Example 53 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(C)CCO)c(N)c1C(N)=O Show InChI InChI=1S/C19H23N5O3/c1-3-27-14-5-4-12-8-13(10-22-15(12)9-14)17-16(19(21)26)18(20)24(23-17)11(2)6-7-25/h4-5,8-11,25H,3,6-7,20H2,1-2H3,(H2,21,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ERG by thallium flux assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.9b00069
BindingDB Entry DOI: 10.7270/Q2GT5RSJ |
More data for this
Ligand-Target Pair | |