Found 6 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM50200560
(CHEMBL3922900 | US9518026, Example 92 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C2CCOC2)c(N)c1C(N)=O Show InChI InChI=1S/C19H21N5O3/c1-2-27-14-4-3-11-7-12(9-22-15(11)8-14)17-16(19(21)25)18(20)24(23-17)13-5-6-26-10-13/h3-4,7-9,13H,2,5-6,10,20H2,1H3,(H2,21,25) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Uncharacterized protein
(Cryptosporidium parvum) | BDBM50200560
(CHEMBL3922900 | US9518026, Example 92 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C2CCOC2)c(N)c1C(N)=O Show InChI InChI=1S/C19H21N5O3/c1-2-27-14-4-3-11-7-12(9-22-15(11)8-14)17-16(19(21)25)18(20)24(23-17)13-5-6-26-10-13/h3-4,7-9,13H,2,5-6,10,20H2,1H3,(H2,21,25) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50200560
(CHEMBL3922900 | US9518026, Example 92 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C2CCOC2)c(N)c1C(N)=O Show InChI InChI=1S/C19H21N5O3/c1-2-27-14-4-3-11-7-12(9-22-15(11)8-14)17-16(19(21)25)18(20)24(23-17)13-5-6-26-10-13/h3-4,7-9,13H,2,5-6,10,20H2,1H3,(H2,21,25) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50200560
(CHEMBL3922900 | US9518026, Example 92 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C2CCOC2)c(N)c1C(N)=O Show InChI InChI=1S/C19H21N5O3/c1-2-27-14-4-3-11-7-12(9-22-15(11)8-14)17-16(19(21)25)18(20)24(23-17)13-5-6-26-10-13/h3-4,7-9,13H,2,5-6,10,20H2,1H3,(H2,21,25) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description Inhibition of recombinant Toxoplasma gondii CDPK1 using Syntide 2 as substrate assessed as decrease in depletion of ATP after 90 mins by Kinase glo l... |
Bioorg Med Chem Lett 26: 5487-5491 (2016)
Article DOI: 10.1016/j.bmcl.2016.10.014 BindingDB Entry DOI: 10.7270/Q2J968BR |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50200560
(CHEMBL3922900 | US9518026, Example 92 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C2CCOC2)c(N)c1C(N)=O Show InChI InChI=1S/C19H21N5O3/c1-2-27-14-4-3-11-7-12(9-22-15(11)8-14)17-16(19(21)25)18(20)24(23-17)13-5-6-26-10-13/h3-4,7-9,13H,2,5-6,10,20H2,1H3,(H2,21,25) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50200560
(CHEMBL3922900 | US9518026, Example 92 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C2CCOC2)c(N)c1C(N)=O Show InChI InChI=1S/C19H21N5O3/c1-2-27-14-4-3-11-7-12(9-22-15(11)8-14)17-16(19(21)25)18(20)24(23-17)13-5-6-26-10-13/h3-4,7-9,13H,2,5-6,10,20H2,1H3,(H2,21,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description Inhibition of human SRC using Ac-EIYGEFKKK as substrate after 90 mins by Kinase glo luciferase assay |
Bioorg Med Chem Lett 26: 5487-5491 (2016)
Article DOI: 10.1016/j.bmcl.2016.10.014 BindingDB Entry DOI: 10.7270/Q2J968BR |
More data for this Ligand-Target Pair | |