Found 6 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Uncharacterized protein
(Cryptosporidium parvum) | BDBM50148635
(CHEMBL3769940 | US9518026, Example 44 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(CC2CC2)c(N)c1C(N)=O Show InChI InChI=1S/C19H21N5O2/c1-2-26-14-6-5-12-7-13(9-22-15(12)8-14)17-16(19(21)25)18(20)24(23-17)10-11-3-4-11/h5-9,11H,2-4,10,20H2,1H3,(H2,21,25) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this
Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM50148635
(CHEMBL3769940 | US9518026, Example 44 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(CC2CC2)c(N)c1C(N)=O Show InChI InChI=1S/C19H21N5O2/c1-2-26-14-6-5-12-7-13(9-22-15(12)8-14)17-16(19(21)25)18(20)24(23-17)10-11-3-4-11/h5-9,11H,2-4,10,20H2,1H3,(H2,21,25) | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50148635
(CHEMBL3769940 | US9518026, Example 44 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(CC2CC2)c(N)c1C(N)=O Show InChI InChI=1S/C19H21N5O2/c1-2-26-14-6-5-12-7-13(9-22-15(12)8-14)17-16(19(21)25)18(20)24(23-17)10-11-3-4-11/h5-9,11H,2-4,10,20H2,1H3,(H2,21,25) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| US Patent
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50148635
(CHEMBL3769940 | US9518026, Example 44 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(CC2CC2)c(N)c1C(N)=O Show InChI InChI=1S/C19H21N5O2/c1-2-26-14-6-5-12-7-13(9-22-15(12)8-14)17-16(19(21)25)18(20)24(23-17)10-11-3-4-11/h5-9,11H,2-4,10,20H2,1H3,(H2,21,25) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50148635
(CHEMBL3769940 | US9518026, Example 44 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(CC2CC2)c(N)c1C(N)=O Show InChI InChI=1S/C19H21N5O2/c1-2-26-14-6-5-12-7-13(9-22-15(12)8-14)17-16(19(21)25)18(20)24(23-17)10-11-3-4-11/h5-9,11H,2-4,10,20H2,1H3,(H2,21,25) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description
Inhibition of Toxoplasma gondii CDPK1 assessed as ATP consumption using (Biotin-C6-PLARTLSVAGLPGKK) as substrate after 90 mins by luciferase reporter... |
ACS Med Chem Lett 6: 1184-1189 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00319
BindingDB Entry DOI: 10.7270/Q2NK3GXD |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50148635
(CHEMBL3769940 | US9518026, Example 44 | US9956214,...)Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(CC2CC2)c(N)c1C(N)=O Show InChI InChI=1S/C19H21N5O2/c1-2-26-14-6-5-12-7-13(9-22-15(12)8-14)17-16(19(21)25)18(20)24(23-17)10-11-3-4-11/h5-9,11H,2-4,10,20H2,1H3,(H2,21,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description
Inhibition of human SRC using Ac-EIYGEFKKK as substrate after 90 mins by luciferase reporter assay |
ACS Med Chem Lett 6: 1184-1189 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00319
BindingDB Entry DOI: 10.7270/Q2NK3GXD |
More data for this
Ligand-Target Pair | |