Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 1
(Mus musculus) | BDBM50065295
(3-[1-(5-Ethyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3...)Show InChI InChI=1S/C15H13NOS/c1-2-10-7-8-11(18-10)9-13-12-5-3-4-6-14(12)16-15(13)17/h3-9H,2H2,1H3,(H,16,17)/b13-9- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc.
Curated by ChEMBL
| Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK). |
J Med Chem 41: 2588-603 (1998)
Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50065295
(3-[1-(5-Ethyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3...)Show InChI InChI=1S/C15H13NOS/c1-2-10-7-8-11(18-10)9-13-12-5-3-4-6-14(12)16-15(13)17/h3-9H,2H2,1H3,(H,16,17)/b13-9- | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc.
Curated by ChEMBL
| Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK). |
J Med Chem 41: 2588-603 (1998)
Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50065295
(3-[1-(5-Ethyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3...)Show InChI InChI=1S/C15H13NOS/c1-2-10-7-8-11(18-10)9-13-12-5-3-4-6-14(12)16-15(13)17/h3-9H,2H2,1H3,(H,16,17)/b13-9- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc.
Curated by ChEMBL
| Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor |
J Med Chem 41: 2588-603 (1998)
Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50065295
(3-[1-(5-Ethyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3...)Show InChI InChI=1S/C15H13NOS/c1-2-10-7-8-11(18-10)9-13-12-5-3-4-6-14(12)16-15(13)17/h3-9H,2H2,1H3,(H,16,17)/b13-9- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc.
Curated by ChEMBL
| Assay Description Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK). |
J Med Chem 41: 2588-603 (1998)
Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT |
More data for this Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50065295
(3-[1-(5-Ethyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3...)Show InChI InChI=1S/C15H13NOS/c1-2-10-7-8-11(18-10)9-13-12-5-3-4-6-14(12)16-15(13)17/h3-9H,2H2,1H3,(H,16,17)/b13-9- | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SUGEN, Inc.
Curated by ChEMBL
| Assay Description Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK) |
J Med Chem 41: 2588-603 (1998)
Article DOI: 10.1021/jm980123i BindingDB Entry DOI: 10.7270/Q2G73CTT |
More data for this Ligand-Target Pair | |