Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM136098
(US8853203, 114 | US9650377, Example 114)Show SMILES CCc1cn(cn1)C1=NCC(=O)N2CCc3c(cccc3C3(F)COC3)C2=C1 |c:30,t:8| Show InChI InChI=1S/C21H21FN4O2/c1-2-14-10-25(13-24-14)19-8-18-16-4-3-5-17(21(22)11-28-12-21)15(16)6-7-26(18)20(27)9-23-19/h3-5,8,10,13H,2,6-7,9,11-12H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce... |
US Patent US9650377 (2017)
BindingDB Entry DOI: 10.7270/Q2G73GT2 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM136098
(US8853203, 114 | US9650377, Example 114)Show SMILES CCc1cn(cn1)C1=NCC(=O)N2CCc3c(cccc3C3(F)COC3)C2=C1 |c:30,t:8| Show InChI InChI=1S/C21H21FN4O2/c1-2-14-10-25(13-24-14)19-8-18-16-4-3-5-17(21(22)11-28-12-21)15(16)6-7-26(18)20(27)9-23-19/h3-5,8,10,13H,2,6-7,9,11-12H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc... |
US Patent US8853203 (2014)
BindingDB Entry DOI: 10.7270/Q2MP520T |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM136098
(US8853203, 114 | US9650377, Example 114)Show SMILES CCc1cn(cn1)C1=NCC(=O)N2CCc3c(cccc3C3(F)COC3)C2=C1 |c:30,t:8| Show InChI InChI=1S/C21H21FN4O2/c1-2-14-10-25(13-24-14)19-8-18-16-4-3-5-17(21(22)11-28-12-21)15(16)6-7-26(18)20(27)9-23-19/h3-5,8,10,13H,2,6-7,9,11-12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc... |
US Patent US9650377 (2017)
BindingDB Entry DOI: 10.7270/Q2G73GT2 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM136098
(US8853203, 114 | US9650377, Example 114)Show SMILES CCc1cn(cn1)C1=NCC(=O)N2CCc3c(cccc3C3(F)COC3)C2=C1 |c:30,t:8| Show InChI InChI=1S/C21H21FN4O2/c1-2-14-10-25(13-24-14)19-8-18-16-4-3-5-17(21(22)11-28-12-21)15(16)6-7-26(18)20(27)9-23-19/h3-5,8,10,13H,2,6-7,9,11-12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc... |
US Patent US8853203 (2014)
BindingDB Entry DOI: 10.7270/Q2MP520T |
More data for this
Ligand-Target Pair | |