Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359135
(US10220048, Compound AA45 | US10952992, No. AA45 |...)Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)C |r| Show InChI InChI=1S/C20H28N4O6S2/c1-5-14-11-31-19(21-14)16(22-18(25)17(12(2)3)23-20(26)30-4)10-13-6-8-15(9-7-13)24-32(27,28)29/h6-9,11-12,16-17,24H,5,10H2,1-4H3,(H,22,25)(H,23,26)(H,27,28,29)/t16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO THERAPEUTICS, INC.
US Patent
| Assay Description HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N... |
US Patent US10220048 (2019)
BindingDB Entry DOI: 10.7270/Q2VT1VC9 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359135
(US10220048, Compound AA45 | US10952992, No. AA45 |...)Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)C |r| Show InChI InChI=1S/C20H28N4O6S2/c1-5-14-11-31-19(21-14)16(22-18(25)17(12(2)3)23-20(26)30-4)10-13-6-8-15(9-7-13)24-32(27,28)29/h6-9,11-12,16-17,24H,5,10H2,1-4H3,(H,22,25)(H,23,26)(H,27,28,29)/t16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RV0SPJ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359135
(US10220048, Compound AA45 | US10952992, No. AA45 |...)Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)C |r| Show InChI InChI=1S/C20H28N4O6S2/c1-5-14-11-31-19(21-14)16(22-18(25)17(12(2)3)23-20(26)30-4)10-13-6-8-15(9-7-13)24-32(27,28)29/h6-9,11-12,16-17,24H,5,10H2,1-4H3,(H,22,25)(H,23,26)(H,27,28,29)/t16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Non-limiting examples of the HPTPβ IC50 (μM) activity. |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2668HD5 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359135
(US10220048, Compound AA45 | US10952992, No. AA45 |...)Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)C |r| Show InChI InChI=1S/C20H28N4O6S2/c1-5-14-11-31-19(21-14)16(22-18(25)17(12(2)3)23-20(26)30-4)10-13-6-8-15(9-7-13)24-32(27,28)29/h6-9,11-12,16-17,24H,5,10H2,1-4H3,(H,22,25)(H,23,26)(H,27,28,29)/t16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO PHARMACEUTICALS, INC.
US Patent
| Assay Description Non-limiting examples of the HPTP-β IC50 (μM) activity. |
US Patent US10952992 (2021)
BindingDB Entry DOI: 10.7270/Q2FR00R3 |
More data for this Ligand-Target Pair | |