Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM50308835
(4-((S)-2-(4-ethylthiazol-2-yl)-2-((S)-2-(methoxyca...)Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](CC(C)C)C(=O)OC |r| Show InChI InChI=1S/C21H29N3O6S2/c1-5-15-12-31-20(22-15)18(23-19(25)17(10-13(2)3)21(26)30-4)11-14-6-8-16(9-7-14)24-32(27,28)29/h6-9,12-13,17-18,24H,5,10-11H2,1-4H3,(H,23,25)(H,27,28,29)/t17-,18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of human protein-tyrosine phosphatase beta |
J Med Chem 53: 2333-44 (2010)
Article DOI: 10.1021/jm901090b BindingDB Entry DOI: 10.7270/Q28P60MB |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50308835
(4-((S)-2-(4-ethylthiazol-2-yl)-2-((S)-2-(methoxyca...)Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](CC(C)C)C(=O)OC |r| Show InChI InChI=1S/C21H29N3O6S2/c1-5-15-12-31-20(22-15)18(23-19(25)17(10-13(2)3)21(26)30-4)11-14-6-8-16(9-7-14)24-32(27,28)29/h6-9,12-13,17-18,24H,5,10-11H2,1-4H3,(H,23,25)(H,27,28,29)/t17-,18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of PTP1B |
J Med Chem 53: 2333-44 (2010)
Article DOI: 10.1021/jm901090b BindingDB Entry DOI: 10.7270/Q28P60MB |
More data for this Ligand-Target Pair | |